| The role of the glucocorticoid receptor in inflammation and immunity. | |
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MedLine Citation:
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PMID: 20346397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucocorticoids are potent immunosuppressive agents with complex actions on immune cells evoking the following effects: inducing apoptosis, changing differentiation fate, inhibition of cytokine release, inhibition of migration and other features. Distinct molecular mechanisms of the glucocorticoid receptor (GR) contribute to different anti-inflammatory effects. Recently inflammatory models have been investigated using conditional knockout and function selective mice shedding light on critical cell types and molecular mechanisms of endogenous and therapeutic GC actions. Here we review the multiple effects of GCs on major immune cells, dendritic cells, myeloid cells and B- and T-lymphocytes and give a summary of studies using conditional GR knockout mice. |
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Authors:
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Ulrike Baschant; Jan Tuckermann |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-24 |
Journal Detail:
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Title: The Journal of steroid biochemistry and molecular biology Volume: 120 ISSN: 1879-1220 ISO Abbreviation: J. Steroid Biochem. Mol. Biol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9015483 Medline TA: J Steroid Biochem Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 69-75 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Leibniz Institute for Age Research - Fritz-Lipmann-Institute, Jena, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucocorticoids / immunology Humans Inflammation / immunology Lymphocytes / immunology Phagocytes / immunology Receptors, Glucocorticoid / deficiency, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Receptors, Glucocorticoid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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