| The Role of Ghrelin, Neuropeptide Y and Leptin Peptides in Weight Gain after Deep Brain Stimulation for Parkinson's Disease. | |
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MedLine Citation:
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PMID: 22398667 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The exact mechanism of weight gain (WG) after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with idiopathic Parkinson's disease remains unknown. Objectives: To investigate a possible involvement of ghrelin, neuropeptide Y (NPY) and leptin in WG after DBS. Methods: Twenty-three Parkinson patients were submitted for body composition measurements and blood sampling 3 days before, and 3 and 6 months after STN DBS. Peripheral concentrations of ghrelin, NPY, and leptin were determined, as well as the L-dopa equivalent daily dose. Patients were clinically evaluated using the Unified Parkinson's Disease Rating Scale. Results: Three months after surgery, a significant WG was observed (3.09 ± 5.00 kg; p = 0.007) with no further increase at 6 months. Three months postoperatively, NPY circulating levels increased significantly (p = 0.05), while the increase of ghrelin levels reached statistical significance at 6 months (p = 0.001). WG was significantly associated with changes of ghrelin and leptin levels at 3 and 6 months, respectively. Conclusions: STN DBS seems to temporarily dysregulate the hypothalamic secretion of NPY and ghrelin. The variation of weight may be attributed to an increased production of ghrelin and leptin. A possible neuroprotective role of DBS, exerted through the increase of ghrelin levels, should be further studied. |
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Authors:
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Elli Markaki; John Ellul; Zinovia Kefalopoulou; Eftichia Trachani; Anastasia Theodoropoulou; Venetsana Kyriazopoulou; Constantine Constantoyannis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-02 |
Journal Detail:
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Title: Stereotactic and functional neurosurgery Volume: 90 ISSN: 1423-0372 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902881 Medline TA: Stereotact Funct Neurosurg Country: - |
Other Details:
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Languages: ENG Pagination: 104-112 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Functional Neurosurgery Unit, Department of Neurosurgery, University of Patras, Rion, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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