Document Detail


The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system.
MedLine Citation:
PMID:  22438035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gap junctions (GJs) are expressed in most cell types of the nervous system, including neuronal stem cells, neurons, astrocytes, oligodendrocytes, cells of the blood brain barrier (endothelial cells and astrocytes) and under inflammatory conditions in microglia/macrophages. GJs connect cells by the docking of two hemichannels, one from each cell with each hemichannel being formed by 6 proteins named connexins (Cx). Unapposed hemichannels (uHC) also can be open on the surface of the cells allowing the release of different intracellular factors to the extracellular space. GJs provide a mechanism of cell-to-cell communication between adjacent cells that enables the direct exchange of intracellular messengers, such as calcium, nucleotides, IP(3), and diverse metabolites, as well as electrical signals that ultimately coordinate tissue homeostasis, proliferation, differentiation, metabolism, cell survival and death. Despite their essential functions in physiological conditions, relatively little is known about the role of GJs and uHC in human diseases, especially within the nervous system. The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system.
Authors:
Eliseo A Eugenin; Daniel Basilio; Juan C Sáez; Juan A Orellana; Cedric S Raine; Feliksas Bukauskas; Michael V L Bennett; Joan W Berman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-03-23
Journal Detail:
Title:  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology     Volume:  7     ISSN:  1557-1904     ISO Abbreviation:  J Neuroimmune Pharmacol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2013-04-10     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101256586     Medline TA:  J Neuroimmune Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  499-518     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport / physiology
Central Nervous System / physiology*
Central Nervous System Diseases / metabolism,  pathology*,  physiopathology*
Gap Junctions / physiology*
Humans
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
AI-051519/AI/NIAID NIH HHS; MH075679/MH/NIMH NIH HHS; MH076679/MH/NIMH NIH HHS; MH083497/MH/NIMH NIH HHS; MH096625/MH/NIMH NIH HHS; NS072238/NS/NINDS NIH HHS; NS55363/NS/NINDS NIH HHS; R01 MH096625/MH/NIMH NIH HHS; R01 NS072238/NS/NINDS NIH HHS
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