| Role of GPR81 in lactate-mediated reduction of adipose lipolysis. | |
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MedLine Citation:
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PMID: 18952058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heavy exercise or oxygen deficit often links with higher levels of arterial lactate and lower levels of plasma free fatty acids (FFA). Treatment with lactate reduces circulating levels of FFA in vivo and lipolysis in adipose tissues in vitro. However, the underlying mechanism has remained unclear. Here we employ pharmacological and genetic approaches to show that GPR81, an orphan G-protein-coupled receptor with relatively restricted expression in the adipose tissues, functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate. GPR81 may thus function as a sensor of lactate that can modulate the FFA pool under exercise or conditions of oxygen deficit. |
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Authors:
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Tian-Quan Cai; Ning Ren; Lan Jin; Kang Cheng; Shera Kash; Ruoping Chen; Samuel D Wright; Andrew K P Taggart; M Gerard Waters |
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Publication Detail:
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Type: Journal Article Date: 2008-10-24 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 377 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-25 Completed Date: 2008-12-15 Revised Date: 2011-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 987-91 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Diseases, Merck Research Laboratories, RY80T-A100, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. tianquan_cai@merck.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism* Animals CHO Cells Cricetinae Cricetulus Fatty Acids, Nonesterified / metabolism* Humans Lactic Acid / metabolism*, pharmacology Ligands Lipolysis* / drug effects, genetics Mice Receptors, G-Protein-Coupled / agonists, genetics, physiology* Receptors, Nicotinic / genetics, physiology Transfection |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/GPR81 protein, human; 0/HCAR2 protein, human; 0/Ligands; 0/Receptors, G-Protein-Coupled; 0/Receptors, Nicotinic; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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