| Role of GABA and opioids in the regulation of the vasopressin response to physical exercise in normal men. | |
| | |
MedLine Citation:
|
PMID: 8278634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was undertaken in order to establish the possible involvement of GABAergic and/or opioid pathways in the mechanism underlying the arginine-vasopressin (AVP) response to physical exercise. After fasting overnight, seven subjects were tested on four mornings at least 1 week apart. Exercise was performed on a bicycle ergometer. The workload was gradually increased at 3 min intervals until exhaustion and lasted about 15 min in all subjects. Tests were carried out under administration of placebo, the opioid antagonist naloxone (10 mg as an i.v. bolus injection), the GABAergic agonist sodium valproate (600 mg in three divided doses orally) or naloxone plus sodium valproate. Plasma AVP levels rose 4-fold during exercise. The administration of naloxone did not modify, whereas sodium valproate completely abolished the plasma AVP rise during exercise. When naloxone was given together with sodium valproate, AVP rose 3-fold in response to exercise. These data suggest the involvement of a GABAergic mechanism in regulation of the AVP response to physical exercise in men. Furthermore, the data argue against a role of naloxone sensitive endogenous opioids in the control of AVP during exercise, whereas they suggest a partial opioid mediation of the GABAergic inhibitory action. |
| | |
Authors:
|
P Chiodera; R Volpi; M L Maffei; A Caiazza; G Caffarri; C Papadia; F Alfano; L Capretti; D Pagani; V Coiro |
Related Documents
:
|
23079864 - Effect of supplemental oxygen on post-exercise inflammatory response and oxidative stress. 16679974 - Nsaid use increases the risk of developing hyponatremia during an ironman triathlon. 21507064 - Effects of different pedalling techniques on muscle fatigue and mechanical efficiency d... 2708234 - Cardiac triacylglycerol content and lipase activity during recovery from exercise. 12370564 - Plasma compartment filling after exercise or heat exposure. 18586134 - Muscle strength and flexibility characteristics of people displaying excessive medial k... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Regulatory peptides Volume: 49 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 1993 Nov |
Date Detail:
|
Created Date: 1994-02-04 Completed Date: 1994-02-04 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 57-63 Citation Subset: IM; S |
Affiliation:
|
Department of Internal Medicine, School of Medicine, University of Parma, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arginine Vasopressin / blood, secretion* Cardiovascular Physiological Phenomena Endorphins / antagonists & inhibitors, physiology* Exercise / physiology* Humans Male Naloxone / pharmacology Respiration / physiology Valproic Acid / pharmacology gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Endorphins; 113-79-1/Arginine Vasopressin; 465-65-6/Naloxone; 56-12-2/gamma-Aminobutyric Acid; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of antrectomy and drug-induced achlorhydria on urinary excretion of N-terminal big gastrin im...
Next Document: Characterization of a calcitonin gene-related peptide (CGRP) receptor on mouse bone marrow cells.