Document Detail

Role of FNAC and antithyroid antibodies in the diagnosis of thyroid disorders.
MedLine Citation:
PMID:  15022905     Owner:  NLM     Status:  MEDLINE    
Multiple parameters are needed to diagnose thyroid disorders. 100 cases of thyroid swellings were studied by clinical assessment, hormonal assay, fine needle aspiration cytology (FNAC), antithyroglobulin (Tg) and antimicrosomal (Tm) antibodies and histopathology. The cases were divided into four groups. Cases of thyroiditis on FNAC showed predominance of lymphocytes (76%), hurthle cells (77%), epithelioid cells and giant cells (31%) and high titres of Tg (66%) and Tm (92%). Non toxic goitre was characterized by colloid and foam cells (100%) and low positivity for Tg and Tm (25%). Toxic goitre showed colloid (30%). Hurthle cells, anisonucleosis of acinar cells (38%), fire flare (62%) and high positivity for Tg and Tm (73%). Neoplasia was diagnosed mainly by cell morphology on FNAC and a low positivity for Tg and Tm (30%). FNAC in correlation with thyroid antibodies is useful in diagnosing autoimmune thyroiditis, goitre, Grave's disease and malignancy of thyroid. Antibodies have a specific role in the diagnosis of early stage of thyroiditis.
Syed Riaz Mehdi; Shaista M Vasenwala; Mohd Shoaib Zaheer; Alifia M Vasenwala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  46     ISSN:  0377-4929     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2004-03-16     Completed Date:  2004-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  184-90     Citation Subset:  IM    
Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh.
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MeSH Terms
Autoantibodies / blood*
Biopsy, Fine-Needle
Goiter / diagnosis,  immunology
Thyroid Diseases / diagnosis*,  immunology*,  pathology
Thyroid Neoplasms / diagnosis,  immunology
Thyroiditis / diagnosis,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/anti-thyroglobulin; 0/thyroid microsomal antibodies

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