| Role of FDG-PET/CT in detection of recurrent disease in colorectal cancer. | |
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MedLine Citation:
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PMID: 20300042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: One-third of patients with colorectal cancer (CRC) are likely to have a recurrence within the first 1-2 years. Conventional imaging modalities have limitations in detecting recurrent disease early. The purpose of this study was to assess the usefulness of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in the detection of recurrence in patients with CRCs. METHODS: One hundred and eighty-three patients, who were earlier treated with surgery and/or chemotherapy/radiotherapy, underwent 269 PET/CT studies for the detection of recurrence. The final diagnosis was made on the basis of histological analysis or clinical and imaging follow-up. RESULTS: The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value in detecting recurrent CRC using F-FDG-PET/CT were 87, 90, 88, 93, and 80%, respectively. PET/CT was found to have limitations in detecting microscopic disease and small-sized lesions. The common cause of false-positive PET/CT results was infective and inflammatory pathology in our setup. CONCLUSION: PET/CT showed high sensitivity, specificity, and accuracy for the detection of recurrent disease in patients, who were earlier treated for CRC. PET/CT can be considered as a useful diagnostic tool in these patients. |
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Authors:
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Shamim Ahmed Shamim; Rakesh Kumar; Dhanapathi Halanaik; Varun Shandal; Rama Mohan Reddy; Chandra Shekhar Bal; Arun Malhotra |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 31 ISSN: 1473-5628 ISO Abbreviation: Nucl Med Commun Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 590-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Colorectal Neoplasms / radiography*, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Positron-Emission Tomography* Recurrence Tomography, X-Ray Computed* Young Adult |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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