Document Detail

Role of FDG-PET and PET/CT in the diagnosis of prolonged febrile states.
MedLine Citation:
PMID:  16572304     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The role of FDG-PET and PET/CT in patients whose main symptom is prolonged fever has not yet been defined. We addressed this topic in a retrospective study. METHODS: A total of 124 patients (referred between May 2001 and December 2004) with fever of unknown origin or prolonged fever due to a suspected infection of a joint or vascular prosthesis were included in the study. The patients underwent either FDG-PET or FDG-PET/CT scanning. Sixty-seven patients had a negative focal FDG-PET finding; in this group the method was regarded as unhelpful in determining a diagnosis, and no further investigation was pursued. We tried to obtain clinical confirmation for all patients with positive PET findings. RESULTS: Fifty-seven (46%) patients had positive FDG-PET findings. In six of them no further clinical information was available. Fifty-one patients with positive PET findings and 118 patients in total were subsequently evaluated. Systemic connective tissue disease was confirmed in 17 patients, lymphoma in three patients, inflammatory bowel disease in two patients, vascular prosthesis infection in seven patients, infection of a hip or knee replacement in seven patients, mycotic aneurysm in two patients, abscess in four patients and AIDS in one patient. In eight (16%) patients the finding was falsely positive. CONCLUSION: FDG-PET or PET/CT contributed to establishing a final diagnosis in 84% of the 51 patients with positive PET findings and in 36% of all 118 evaluated patients with prolonged fever.
M Jaruskova; O Belohlavek
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Publication Detail:
Type:  Journal Article     Date:  2006-03-30
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  33     ISSN:  1619-7070     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  913-8     Citation Subset:  IM    
PET Center, Na Homolce Hospital, Roentgenova 2, 150 30, Prague 5, Czech Republic.
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MeSH Terms
Chronic Disease
Fever / diagnosis*,  etiology
Fever of Unknown Origin / diagnosis
Fluorodeoxyglucose F18 / diagnostic use*
Positron-Emission Tomography / methods*
Prosthesis-Related Infections / complications,  diagnosis*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Subtraction Technique
Tomography, X-Ray Computed / methods*
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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