Document Detail

Role of Exogenous and Endogenous Sources of Estrogen on the Incidence of Breast Fibroadenoma: Case-control Study in Iran.
MedLine Citation:
PMID:  21875284     Owner:  NLM     Status:  In-Data-Review    
Breast fibroadenoma (FAD) is the most common benign mammary condition among women but the environmental risk factors have not identified yet. As the role of long term estrogen exposure in the incidence of FAD has been remained controversial; we have decided to investigate the possible role of endogenous and exogenous sources of estrogens in present study. Women less than 45 years old who underwent surgery from June 2009 to June 2010 were matched with controls by age and hospital. From reproductive factors, lack of breast feeding (p< 0.001, 8.76 CI95% 3.79-20.24), Nulliparity (p=0.001, OR=8.09, CI95% 3.505-18.67), Lack of parity (p=0.001, OR=6.64, CI 95% 2.56-16.31) and Hormonal dysfunction (p=0.016, OR=4.66, CI 95% 1.26- 17.28) were considered as the most important ones. Adiposity and abnormal weight gain after 18 years were considered as major background factor which induce FAD and may be contributed to the level of endogenous estrogen. Out of evaluated exogenous sources of estrogen, lower age at first OCP consumption (20.76_+3.87 vs. 22.85_+3.88, p=0.046) and living near Polycyclic aromatic hydrocarbons (PAHs) producing factories (p< 0.001, OR=3.7, CI95%1.61-7.94), were considered as the main sources of exposure to xenestrogens in FAD patients but FAD showed inverse association with cigarette smoking because of antiestrogenic activities of cigarette smoking . This study concludes that the incidence and development of FAD could be associated with the reproductive history of women, activity of ovarian hormones as well as environmental factors.
Sepideh Arbabi Bidgoli; Tara Eftekhari
Related Documents :
16157834 - Prospective cohort study of soy food consumption and risk of bone fracture among postme...
3074564 - A practical guide to preventing osteoporosis.
21771774 - Factors affecting obstetric outcome of singletons born after ivf.
22076554 - Change in self-efficacy, autonomous and controlled motivation predicting smoking.
20021624 - Postprandial metabolic responses to dietary glycemic index in hypercholesterolemic post...
18818024 - Influence of phase-related variability in premenstrual symptomatology, mood, smoking wi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  12     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1289-93     Citation Subset:  IM    
Dept. of Toxicology and Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University(IAUPS), Tehran, Iran E-mail,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Validation of the Turkish versions of EORTC QLQ-C30 and BR23 modules in breast cancer patients.
Next Document:  Level of Cancer Awareness among Women of Low Socioeconomic Status in Mumbai Slums.