| The Role of Endocytic Pathways in TGF-β Signaling. | |
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MedLine Citation:
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PMID: 23274761 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transforming growth factor β (TGF-β) superfamily consists of numerous cytokins that regulate various cellular processes. TGF-β, the prototype of the family, signals through its cell surface serine/threonin kinase receptors and besides its role in cell differentiation, migration, adhesion etc. it is also able to induce epithelial-mesenchymal (EMT) transition via both Smad- pathway and MAPK- pathway. Among the different types of epithelial-mesenchymal transition, type II that is described to be associated with wound healing, tissue regeneration, organ fibrosis and is induced upon inflammatory stimuli. It can be triggered by secretion of growth factors such as TGF-β, EGF. Different endocytic routes are used for the internalization of TGF-β ligand and its receptors and these pathways can control the activity of downstream events. Internalization via clathrin-coated vesicles promotes the signaling while the caveola-mediated endocytosis plays important role in the termination of the events, although the steps of the latter event are less clear. The early endosome is considered a clue compartment in promoting the signaling. Recently published data suggest that the early endosome plays crucial role in the termination of the TGFβ signaling as well. It is not only maintain a special environment for the effective signaling but can direct the internalized cargos towards degradative pathways (multivesicular bodies, lysosomes). |
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Authors:
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P Balogh; S Katz; A L Kiss |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-30 |
Journal Detail:
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Title: Pathology oncology research : POR Volume: - ISSN: 1532-2807 ISO Abbreviation: Pathol. Oncol. Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706087 Medline TA: Pathol Oncol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Human Morphology and Developmental Biology, Semmelweis University, Tűzoltó u. 58, Budapest, 1094, Hungary, balogh.petra@med.semmelweis-univ.hu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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