Document Detail


The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans.
MedLine Citation:
PMID:  24932427     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In a murine model, we have linked early life toxicant exposure to reduced uterine sensitivity to progesterone, a phenotype we had previously associated with inflammation in endometriosis patients. Subsequent studies revealed that developmental toxicant exposure not only reduces fertility in male and female mice but also negatively impacts pregnancy leading to spontaneous preterm birth (PTB). An epigenetic alteration of the progesterone receptor gene correlated with reduced fertility and adverse pregnancy outcomes and persisted in multiple generations of mice in the absence of an additional toxicant exposure. Gene-environment interactions in women may explain why some patients "at risk" for PTB deliver at term while others without known risks deliver early. Our model provides a unique system to unravel the interactive influences of inflammation and reduced progesterone responsiveness on PTB and suggests that therapy needs to begin prior to pregnancy (and involve both partners) rather than once the inflammatory cascade has been initiated.
Authors:
Kaylon L Bruner-Tran; David Resuehr; Tianbing Ding; John A Lucas; Kevin G Osteen
Related Documents :
16808137 - Effects of pregnancy on the army physical fitness test.
11223357 - Maternal serum leptin concentrations do not correlate with cord blood leptin concentrat...
8798297 - Maternal lean body mass and birth-weight.
11444787 - Oxidant damage to dna and pregnancy outcome.
22116647 - Effects of embryo transfer quality on pregnancy and live birth delivery rates.
9587807 - Electra versus oedipus. femininity reconsidered.
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Current obstetrics and gynecology reports     Volume:  1     ISSN:  2161-3303     ISO Abbreviation:  Curr Obstet Gynecol Rep     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2014-6-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101579335     Medline TA:  Curr Obstet Gynecol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  116-123     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 ES014942/ES/NIEHS NIH HHS; R21 AT006245/AT/NCCAM NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Brittle Dyskinesia Following STN but not GPi Deep Brain Stimulation.
Next Document:  Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.