| Role of Early Postradiation Magnetic Resonance Imaging Scans in Children with Diffuse Intrinsic Pontine Glioma. | |
| | |
MedLine Citation:
|
PMID: 22280788 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To determine optimal timing of assessing postradiation radiographic response on magnetic resonance imaging (MRI) scans in pediatric patients with diffuse intrinsic pontine glioma (DIPG). METHODS AND MATERIALS: Patients were treated on a prospective study at the National Cancer Institute (Protocol #06-C-0219) evaluating the effects of radiotherapy (RT). Standard RT was administered in standard fractionation over 6 weeks. Postradiation MRI scans were performed at 2 and 6-8 weeks. RESULTS: Eleven patients with DIPG were evaluated. Median age was 6 years (range, 4-13 years). Patients were treated with external-beam RT to 55.8 Gy (n = 10) or 54 Gy (n = 1), with a gross tumor volume to planning target volume expansion of 1.8-2.0 cm. All patients received prescribed dose and underwent posttreatment MRI scans at 2 and 6-8 weeks. Pretreatment imaging revealed compression of fourth ventricle (n = 11); basilar artery encasement (n = 9); tumor extension outside the pons (n = 11); and tumor hemorrhage (n = 2). At the 2-week scan, basilar artery encasement improved in 7 of 9 patients, and extent of tumor was reduced in 5 of 11 patients. Fourth ventricle compression improved in 6 of 11 patients but worsened in 3 of 11 patients. Presumed necrosis was observed in 5 of 11 patients at 2 weeks and in 1 additional patient at 6-8 weeks. There was no significant difference in mean anteroposterior and transverse diameters of tumor between the 2- and 6-8-week time points. Six of 11 patients had increasing ventricular size, with no evidence of obstruction. CONCLUSIONS: There is no significant difference in tumor size of DIPG patients who have received standard RT when measured at 2 weeks vs. 6-8 weeks after RT. The majority of patients had the largest change in tumor size at the 2-week post-RT scan, with evolving changes documented on the 6-8-week scan. Six of 11 patients had progressive ventriculomegaly without obstruction, suggestive of communicating hydrocephalus. To the best of our knowledge, this is the first documentation of this phenomenon in this cohort of patients. |
| | |
Authors:
|
Christine Ko; Aradhana Kaushal; Dima A Hammoud; Emilie A Steffen-Smith; Robyn Bent; Deborah Citrin; Kevin Camphausen; Katherine E Warren |
Related Documents
:
|
22343978 - Incidence of acute pancreatitis in human immunodeficiency virus-positive patients with ... 8077258 - Myelomeningocele at the sacral level. long-term outcomes in adults. 21833018 - Black patients of african descent and hla-drb1*15:03 frequency overrepresented in epide... 16394908 - An open-label study to evaluate the safety and efficacy of tissue plasminogen activator... 3162698 - Clinicopathological study of hematological disorders after thorotrast administration in... 6830348 - Therapeutic and diagnostic colonoscopy in nonobstructive colonic dilatation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: - ISSN: 1879-355X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effective interactions in lysozyme aqueous solutions: A small-angle neutron scattering and computer ...
Next Document: Gallbladder Needle Decompression During Radiofrequency Ablation of an Adjacent Liver Tumour.