Document Detail

The role of delayed 18F-FDG PET imaging in the follow-up of patients with alveolar echinococcosis.
MedLine Citation:
PMID:  23303963     Owner:  NLM     Status:  MEDLINE    
METHODS: During a 6-y period, 120 PET scans using (18)F-FDG were obtained for 70 AE patients treated by benzimidazoles, without selection. All patients underwent whole-body imaging on a PET/CT device 1 h after (18)F-FDG injection (4 MBq/kg), as well as an acquisition focused on the liver 3 h after the injection. We also analyzed the results of serologic tests.
RESULTS: Of the 57 scans considered negative at the standard acquisition, 13 (22.8%) became clearly positive at the delayed acquisition, and 6 (10.5%) became indeterminate at the delayed acquisition. Furthermore, 20 of 22 scans interpreted as indeterminate at the standard acquisition were considered positive because of clear perilesional (18)F-FDG uptake at the delayed acquisition. Thus, delayed acquisition changed the interpretation in 32.5% of cases. Moreover, of 44 patients treated by benzimidazoles and followed for more than 2 y by regular (18)F-FDG PET scans and specific AE serology, 11 (25%) presented pathologic (18)F-FDG uptake at the delayed acquisition but not at the standard one. In these patients, the treatment was continued despite negative results on standard (18)F-FDG PET and negative serologic findings. On the other hand, in 7 patients with negative delayed (18)F-FDG PET and negative serology, the treatment was safely interrupted with no evidence of disease recurrence during 8-37 mo (mean, 23 mo).
CONCLUSION: Our study clearly demonstrated that delayed (18)F-FDG PET greatly facilitated the differentiation between active and inactive liver lesions in AE patients. Also, our results strongly suggested that the combination of delayed (18)F-FDG PET and specific serology would prevent most of the recurrences observed after premature interruption of the treatment based only on standard (18)F-FDG PET.
Cécile Caoduro; Clémence Porot; Dominique A Vuitton; Solange Bresson-Hadni; Frédéric Grenouillet; Carine Richou; Hatem Boulahdour; Oleg Blagosklonov
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-01-09
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  54     ISSN:  1535-5667     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-04-24     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-63     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Anthelmintics / therapeutic use
Antigens, Helminth
Benzimidazoles / therapeutic use
Child, Preschool
Echinococcosis, Hepatic / drug therapy,  parasitology,  radionuclide imaging*
Echinococcus / immunology
Fluorine Radioisotopes / diagnostic use
Fluorodeoxyglucose F18 / diagnostic use
Middle Aged
Positron-Emission Tomography*
Prospective Studies
Radiopharmaceuticals / diagnostic use
Time Factors
Young Adult
Reg. No./Substance:
0/Anthelmintics; 0/Antigens, Helminth; 0/Benzimidazoles; 0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 0Z5B2CJX4D/Fluorodeoxyglucose F18
Comment In:
Rofo. 2013 Nov;185(11):1030   [PMID:  24308050 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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