Document Detail

Role of defibrillation threshold testing in the contemporary defibrillator patient population.
MedLine Citation:
PMID:  23210803     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Defibrillation threshold (DFT) testing has been performed to prove functionality of the implantable cardioverter defibrillator (ICD). Over the past years it has become increasingly controversial because of possible morbidity and mortality. The goal of this study was to determine unsuccessful shock testing and report strategies used to overcome these problems.
METHODS AND RESULTS: A total of 314 patients with a de novo implantation of an ICD and 127 patients receiving a generator exchange were identified retrospectively. All patients underwent defibrillation threshold testing after induction of VF using a low-energy T-wave shock during the intervention, 2 shock tests after de novo implantations, 1 after generator change. A safety margin of 10 J or more was requested. Seven (2.3%) patients in the de novo group and 2 patients (1.4%) in the generator exchange group could not be defibrillated using the standard approach. All of those patients had either chronic amiodarone therapy, secondary prevention or a cardiac resynchronization therapy device (CRT). In univariate analysis, amiodarone therapy, dilated cardiomyopathy, and lower ejection fraction were predictors of failure.
CONCLUSION: Our study's results as well as a review of the current literature favor shock testing, especially in patients with specific risk factors as mentioned above.
Annina S Vischer; Christian Sticherling; Michael S Kühne; Stefan Osswald; Beat A Schaer
Related Documents :
25228313 - Determining sample size when assessing mean equivalence.
23040293 - Munix and incremental stimulation mune in als patients and control subjects.
23520053 - Mucosal brush biopsy of the oral cavity to detect local, peanut-specific immunoglobulin e.
Publication Detail:
Type:  Journal Article     Date:  2012-12-04
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  24     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-04     Completed Date:  2013-09-30     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-41     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amiodarone / therapeutic use
Anti-Arrhythmia Agents / therapeutic use
Cardiac Resynchronization Therapy Devices
Cardiomyopathy, Dilated / complications
Defibrillators, Implantable*
Device Removal
Electric Countershock / instrumentation*
Electrophysiologic Techniques, Cardiac*
Equipment Safety
Heart Failure / etiology,  physiopathology,  therapy*
Materials Testing
Middle Aged
Predictive Value of Tests
Prosthesis Design
Prosthesis Failure
Retrospective Studies
Risk Factors
Stroke Volume
Treatment Outcome
Ventricular Fibrillation / etiology,  physiopathology,  prevention & control*
Ventricular Function, Left
Reg. No./Substance:
0/Anti-Arrhythmia Agents; N3RQ532IUT/Amiodarone
Comment In:
J Cardiovasc Electrophysiol. 2013 Dec;24(12):E18   [PMID:  24028634 ]
J Cardiovasc Electrophysiol. 2013 Dec;24(12):E19   [PMID:  24020827 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Over-ground walking on level and sloped surfaces in people with stroke compared to healthy matched a...
Next Document:  Determination of Benzotriazoles and Benzothiazoles in Human Urine by Liquid Chromatography-Tandem Ma...