| Role of Defensins and Cathelicidin LL37 in Auto-immune and Auto-inflammatory diseases. | |
| | |
MedLine Citation:
|
PMID: 22250708 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Defensins and cathelicidins are anti-microbial peptides (AMPs) that act as natural antibiotics and are part of the innate immune defence in many species. We consider human defensins and LL37, the only human member of the cathelicidin family. In particular, we refer to the human alpha-defensins called human neutrophil peptides (HNP1 through 4), which are produced by neutrophils, HD5 and HD6, mainly expressed in Paneth cells of intestine, the human beta-defensins HBD1, HBD2 and HBD3, synthesized by epithelial cells and LL37, which is located in granulocytes, but is also produced by epithelial cells of the skin, lungs, and gut. In the last years, the study of AMPs activity and regulation has allowed to understand the important role of these peptides not only in the innate defence mechanisms against bacteria, viruses, fungi, but also in the regulation of immune cell activation and migration. Complementary studies have disclosed a role for AMPs in modulating many physiological processes that involve non-immune cells, such as activation of woud healing, angiogenesis, cartilage remodeling. Due to the pleiotropic tasks of these peptides, many of them are now being discovered to contribute to immune pathology of chronic diseases that affect skin, gut, joints; this is supported by many examples of immune-mediated pathologies in which their expression is disregulated. In this article we review the current literature that suggests a role for human defensins and LL37 in pathogenic mechanisms of several chronic diseases that are considered of auto-immune or auto-inflammatory origin. |
| | |
Authors:
|
Loredana Frasca; Roberto Lande |
Related Documents
:
|
21741878 - Mucosal biofilms of candida albicans. 16645228 - Impact of growth factors in the regulation of apoptosis in low-risk myelodysplastic syn... 11522448 - Impaired accumulation of granulocytes in the lung during ozone adaptation. 9780208 - Factor xa induces cytokine production and expression of adhesion molecules by human umb... 21190998 - Il-29 and ifn{alpha} differ in their ability to modulate il-12 production by tlr-activa... 20628358 - A short pulse of il-4 delivered by dcs electroporated with modified mrna can both preve... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
|
Title: Current pharmaceutical biotechnology Volume: - ISSN: 1873-4316 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
L.F. at the Department of Infectious, Parasitic and Immune-mediated diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. rolande@iss.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Psoriasis, from pathogenesis to therapeutic strategies: IL-21 as a novel potential therapeutic targe...
Next Document: New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data int...