| Role of Decreased Circulating Hepcidin Concentrations in the Iron Excess of Women with the Polycystic Ovary Syndrome. | |
| | |
MedLine Citation:
|
PMID: 21209031 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context: Hepcidin inhibits the intestinal absorption of iron and its deficiency causes juvenile hemochromatosis. Objective: The objective of the investigation was to study the involvement of hepcidin in the iron overload of patients with polycystic ovary syndrome (PCOS). Design: This was a case-control study followed by a randomized clinical trial. Setting: The study was conducted at an academic hospital. Patients: Thirty-four patients with PCOS and 30 women without hyperandrogenism, matched for age and body mass index, participated in the study. Intervention: Patients with PCOS were randomly allocated to treatment with either an antiandrogenic oral contraceptive or metformin for 24 wk. Main Outcome Measures: Serum hepcidin levels and ferritin to hepcidin molar ratios were measured. Results: Patients with PCOS showed decreased circulating hepcidin levels and increased ferritin to hepcidin molar ratios compared with controls. Patients with PCOS presenting with chronic oligoamenorrhea (an iron sparing mechanism) showed a paradoxical decrease in serum hepcidin levels and an increase in ferritin to hepcidin molar ratios compared with the patients who had regular anovulatory menstrual cycles and with the controls. The major predictor of circulating hepcidin concentrations was the presence of PCOS, whereas the main determinants of the ferritin to hepcidin molar ratio were the insulin sensitivity index and menstrual dysfunction. Serum hepcidin levels did not change during treatment with either metformin or the antiandrogenic oral contraceptive pill, yet patients treated with the oral contraceptive pill normalized the ferritin to hepcidin molar ratio. Conclusions: Patients with PCOS had reduced serum hepcidin concentrations that might contribute to their iron overload by favoring the intestinal absorption of iron. The imbalance between increased iron stores and reduced hepcidin levels was related to the insulin resistance and androgen excess characteristic of this syndrome. |
| | |
Authors:
|
Manuel Luque-Ramírez; Francisco Alvarez-Blasco; Macarena Alpañés; Héctor F Escobar-Morreale |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-5 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Endocrinology, Hospital Universitario Ramón y Cajal and Universidad de Alcalá and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, E-28034 Madrid, Spain; and Centro de Investigación Biomédica en Red y Enfermedades Metabólicas Asociadas, E-08036 Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Independent and Combined Effects of Calcium-Vitamin D3 and Exercise on Bone Structure and Strength i...
Next Document: Extrinsic Mechanisms Involved in Age-Related Defective Bone Formation.