| The role of combined assessment of defense against oxidative stress and inflammation in the evaluation of peripheral arterial disease. | |
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MedLine Citation:
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PMID: 21663591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis in symptomatic peripheral arterial disease affects wide portions of numerous arteries in lower extremities. The resulting active inflammation in a considerable amount of arterial tissue facilitates systemic detection via measurement of inflammation-related variables. We reasoned that the combined assessment of defense against oxidative stress, in the form of paraoxonase-1 (PON1), and monocyte migration measured as circulating (C-C motif) ligand 2 (CCL2), may play a role in the evaluation of these patients. Plasma CCL2 and serum PON1-related variables, assessed by their interaction with functional genetic variants, were measured in a cross-sectional study in patients with symptomatic PAD. We found that PON1 activity and concentration were significantly lower and CCL2 concentration higher in PAD patients compared to controls, that the combination of plasma CCL2 and PON1- related values, especially PON1 concentration differentiated, almost perfectly, controls from patients and that the expression of CCL2 and PON1 generally co-localized in the atherosclerotic lesion. Since no association with genetic variants was found, such a relationship is probably the result of the disease. Our data suggest a coordinated role between CCL2 and PON1 that may be detected in blood with simple measurements and may represent an indicator of the extent of atherosclerosis. |
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Authors:
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A Rull; R García; L Fernández-Sender; R Beltrán-Debón; G Aragonès; J M Alegret; C Alonso-Villaverde; B Mackness; M Mackness; J Camps; V Martin-Paredero; J Joven |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current molecular medicine Volume: 11 ISSN: 1875-5666 ISO Abbreviation: Curr. Mol. Med. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-16 Completed Date: 2012-01-25 Revised Date: 2012-03-02 |
Medline Journal Info:
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Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 453-64 Citation Subset: IM |
Affiliation:
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Centre de Recerca Biomèdica, IISPV, Universitat Rovira i Virgili, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aryldialkylphosphatase / blood*, genetics Atherosclerosis / metabolism*, pathology Chemokine CCL2 / blood*, genetics Cross-Sectional Studies Humans Male Middle Aged Oxidative Stress Peripheral Arterial Disease / blood*, drug therapy, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/CCL2 protein, human; 0/Chemokine CCL2; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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