Document Detail


The role of combined assessment of defense against oxidative stress and inflammation in the evaluation of peripheral arterial disease.
MedLine Citation:
PMID:  21663591     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis in symptomatic peripheral arterial disease affects wide portions of numerous arteries in lower extremities. The resulting active inflammation in a considerable amount of arterial tissue facilitates systemic detection via measurement of inflammation-related variables. We reasoned that the combined assessment of defense against oxidative stress, in the form of paraoxonase-1 (PON1), and monocyte migration measured as circulating (C-C motif) ligand 2 (CCL2), may play a role in the evaluation of these patients. Plasma CCL2 and serum PON1-related variables, assessed by their interaction with functional genetic variants, were measured in a cross-sectional study in patients with symptomatic PAD. We found that PON1 activity and concentration were significantly lower and CCL2 concentration higher in PAD patients compared to controls, that the combination of plasma CCL2 and PON1- related values, especially PON1 concentration differentiated, almost perfectly, controls from patients and that the expression of CCL2 and PON1 generally co-localized in the atherosclerotic lesion. Since no association with genetic variants was found, such a relationship is probably the result of the disease. Our data suggest a coordinated role between CCL2 and PON1 that may be detected in blood with simple measurements and may represent an indicator of the extent of atherosclerosis.
Authors:
A Rull; R García; L Fernández-Sender; R Beltrán-Debón; G Aragonès; J M Alegret; C Alonso-Villaverde; B Mackness; M Mackness; J Camps; V Martin-Paredero; J Joven
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current molecular medicine     Volume:  11     ISSN:  1875-5666     ISO Abbreviation:  Curr. Mol. Med.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-16     Completed Date:  2012-01-25     Revised Date:  2012-03-02    
Medline Journal Info:
Nlm Unique ID:  101093076     Medline TA:  Curr Mol Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  453-64     Citation Subset:  IM    
Affiliation:
Centre de Recerca Biomèdica, IISPV, Universitat Rovira i Virgili, Spain.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aryldialkylphosphatase / blood*,  genetics
Atherosclerosis / metabolism*,  pathology
Chemokine CCL2 / blood*,  genetics
Cross-Sectional Studies
Humans
Male
Middle Aged
Oxidative Stress
Peripheral Arterial Disease / blood*,  drug therapy,  genetics,  metabolism
Chemical
Reg. No./Substance:
0/CCL2 protein, human; 0/Chemokine CCL2; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human

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