| Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. | |
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MedLine Citation:
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PMID: 21054166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 18 glycosyl hydrolase family of chitinases is an ancient gene family that is widely expressed from prokaryotes to eukaryotes. In mammals, despite the absence of endogenous chitin, a number of chitinases and chitinase-like proteins (C/CLPs) have been identified. However, their roles have only recently begun to be elucidated. Acidic mammalian chitinase (AMCase) inhibits chitin-induced innate inflammation; augments chitin-free, allergen-induced Th2 inflammation; and mediates effector functions of IL-13. The CLPs BRP-39/YKL-40 (also termed chitinase 3-like 1) inhibit oxidant-induced lung injury, augments adaptive Th2 immunity, regulates apoptosis, stimulates alternative macrophage activation, and contributes to fibrosis and wound healing. In accord with these findings, levels of YKL-40 in the lung and serum are increased in asthma and other inflammatory and remodeling disorders and often correlate with disease severity. Our understanding of the roles of C/CLPs in inflammation, tissue remodeling, and tissue injury in health and disease is reviewed below. |
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Authors:
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Chun Geun Lee; Carla A Da Silva; Charles S Dela Cruz; Farida Ahangari; Bing Ma; Min-Jong Kang; Chuan-Hua He; Seyedtaghi Takyar; Jack A Elias |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of physiology Volume: 73 ISSN: 1545-1585 ISO Abbreviation: Annu. Rev. Physiol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-07-08 Revised Date: 2012-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0370600 Medline TA: Annu Rev Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 479-501 Citation Subset: IM |
Affiliation:
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Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8057, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines Airway Remodeling / physiology* Animals Apoptosis / immunology Atherosclerosis / enzymology, immunology Chitin / immunology, metabolism* Chitinase / immunology, metabolism* Diabetes Mellitus / enzymology, immunology Giant Cell Arteritis / enzymology, immunology Glycoproteins / blood, physiology Humans Inflammation / enzymology* Lectins / blood, physiology Lung Diseases / enzymology, immunology Mice Neoplasms / enzymology, immunology Oxidative Stress / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins; 0/chitinase 3-like 1, mouse; 1398-61-4/Chitin; EC 3.2.1.14/Chitinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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