| The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts. | |
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MedLine Citation:
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PMID: 20165554 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Collective cell motility and its guidance via cell-cell contacts is instrumental in several morphogenetic and pathological processes such as vasculogenesis or tumor growth. Multicellular sprout elongation, one of the simplest cases of collective motility, depends on a continuous supply of cells streaming along the sprout towards its tip. The phenomenon is often explained as leader cells pulling the rest of the sprout forward via cell-cell adhesion. Building on an empirically demonstrated analogy between surface tension and cell-cell adhesion, we demonstrate that such a mechanism is unable to recruit cells to the sprout. Moreover, the expansion of such hypothetical sprouts is limited by a form of the Plateau-Taylor instability. In contrast, actively moving cells - guided by cell-cell contacts - can readily populate and expand linear sprouts. We argue that preferential attraction to the surfaces of elongated cells can provide a generic mechanism, shared by several cell types, for multicellular sprout formation. |
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Authors:
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A Szabó; A Czirók |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Mathematical modelling of natural phenomena Volume: 5 ISSN: 1760-6101 ISO Abbreviation: - Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101512243 Medline TA: Math Model Nat Phenom Country: - |
Other Details:
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Languages: ENG Pagination: 106 Citation Subset: - |
Affiliation:
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Department of Biological Physics, Eötvos University, Budapest, Hungary. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL087136-03//NHLBI NIH HHS |
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