Document Detail

Role of CD36 in membrane transport and utilization of long-chain fatty acids by different tissues.
MedLine Citation:
PMID:  11478366     Owner:  NLM     Status:  MEDLINE    
The transmembrane glycoprotein CD36 has been identified in isolated cell studies as a putative transporter of long-chain fatty acids. To examine the physiological role of CD36, we studied FA uptake and metabolism by tissues of CD36 null mice after injection with two fatty acid analogs. Compared to controls, uptake was substantially reduced (50-80%) in heart, skeletal muscle, and adipose tissues of null mice. The reduction in uptake was associated with a large decrease in fatty acid incorporation into triglycerides, which could be accounted for by an accumulation of diacylglycerides. Thus CD36 facilitates a major fraction of fatty acid uptake by myocardial, skeletal muscle, and adipose tissues, where it is highly expressed. Its role in other tissues where its expression is low and cell-specific could not be determined in these studies.
C T Coburn; T Hajri; A Ibrahimi; N A Abumrad
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of molecular neuroscience : MN     Volume:  16     ISSN:  0895-8696     ISO Abbreviation:  J. Mol. Neurosci.     Publication Date:    2001 Apr-Jun
Date Detail:
Created Date:  2001-07-31     Completed Date:  2002-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002991     Medline TA:  J Mol Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-21; discussion 151-7     Citation Subset:  IM    
Department of Physiology, State University of New York at Stony Brook, 11794-8661, USA.
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MeSH Terms
Adipocytes / metabolism
Animals, Congenic
Antigens, CD36 / genetics,  physiology*
Biological Transport
Blood Platelets / metabolism
Brain / metabolism
Cell Membrane Permeability / physiology*
Disease Models, Animal
Fatty Acids / metabolism*
Hypertension / genetics,  metabolism
Insulin Resistance / genetics
Membrane Glycoproteins / deficiency,  genetics,  physiology*
Mice, Knockout
Muscle, Skeletal / metabolism
Myocardium / metabolism
Nerve Tissue Proteins / metabolism
Organ Specificity
Organic Anion Transporters / deficiency,  genetics,  physiology*
Quantitative Trait, Heritable
Rats, Inbred SHR
Triglycerides / metabolism
Reg. No./Substance:
0/Antigens, CD36; 0/Fatty Acids; 0/Membrane Glycoproteins; 0/Nerve Tissue Proteins; 0/Organic Anion Transporters; 0/Triglycerides

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