Document Detail


Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry.
MedLine Citation:
PMID:  18436785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The asymmetrical distribution of phospholipids on the plasma membrane is critical for maintaining cell integrity and physiology and for regulating intracellular signaling and important cellular events such as clearance of apoptotic cells. How phospholipid asymmetry is established and maintained is not fully understood. We report that the Caenorhabditis elegans P-type adenosine triphosphatase homolog, TAT-1, is critical for maintaining cell surface asymmetry of phosphatidylserine (PS). In animals deficient in tat-1, PS is abnormally exposed on the cell surface, and normally living cells are randomly lost through a mechanism dependent on PSR-1, a PS-recognizing phagocyte receptor, and CED-1, which contributes to recognition and engulfment of apoptotic cells. Thus, tat-1 appears to function in preventing appearance of PS in the outer leaflet of plasma membrane, and ectopic exposure of PS on the cell surface may result in removal of living cells by neighboring phagocytes.
Authors:
Monica Darland-Ransom; Xiaochen Wang; Chun-Ling Sun; James Mapes; Keiko Gengyo-Ando; Shohei Mitani; Ding Xue
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  320     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-05-07     Revised Date:  2013-10-29    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-31     Citation Subset:  IM    
Affiliation:
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Apoptosis
Caenorhabditis elegans / cytology,  genetics,  metabolism*
Caenorhabditis elegans Proteins / genetics,  metabolism*
Cell Membrane / metabolism*
Germ Cells / cytology,  metabolism
Muscle Cells / cytology,  metabolism
Neurons / cytology,  metabolism
Phagocytosis
Phosphatidylserines / metabolism*
Phospholipid Transfer Proteins / genetics,  metabolism*
RNA Interference
Recombinant Fusion Proteins / metabolism
Grant Support
ID/Acronym/Agency:
R01 GM59083/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Phosphatidylserines; 0/Phospholipid Transfer Proteins; 0/Recombinant Fusion Proteins; EC 3.6.1.-/TAT-1 protein, C elegans
Comments/Corrections
Comment In:
Science. 2008 Apr 25;320(5875):458-60   [PMID:  18436763 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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