Document Detail

The Role of C-Terminal Binding Protein 2 in Schwann Cell Differentiation After Sciatic Nerve Crush.
MedLine Citation:
PMID:  23138653     Owner:  NLM     Status:  Publisher    
C-terminal binding protein 2 (CtBP2), as a transcriptional repressor, plays an essential role in development and tumorigenesis. However, its distribution and function in peripheral system lesion and repair are still unknown. Here, we investigated the spatiotemporal expression of CtBP2 in rat sciatic nerve crush model. Western blot analysis revealed that CtBP2 was expressed in normal sciatic nerve. It gradually decreased, reached minimal levels at 7 days after crush, and then returned to the normal level at 4 weeks. We observed that CtBP2 is mainly expressed in Schwann cells (SCs). In vitro, we induced SC differentiation via cyclic adenosine monophosphate (cAMP) and found that CtBP2 expression was downregulated during the process of differentiation. CtBP2-specific siRNA inhibited the cAMP-induced expression of the immature SC marker P75(NTR), and exogenous CtBP2 expression upregulated the expression of P75(NTR). Taken together, we hypothesized that peripheral nerve crush-induced downregulation of CtBP2 in the sciatic nerve was associated with SC differentiation, and CtBP2 likely played an important role in peripheral nerve injury and regeneration.
Xingjian Cao; Ping Zhao; Guohua Tao; Yihua Zhu; Feng Zhou; Zhiming Cui; Guofeng Bao; Dawei Xu; Guowei Zhang; Xiang Chen
Related Documents :
23274483 - Altered long noncoding rna expressions in dorsal root ganglion after rat sciatic nerve ...
8756003 - Heparin-binding epidermal growth factor-like growth factor regulates fibroblast growth ...
8999813 - Cloning of an apobec-1-binding protein that also interacts with apolipoprotein b mrna a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Journal of molecular neuroscience : MN     Volume:  -     ISSN:  1559-1166     ISO Abbreviation:  J. Mol. Neurosci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002991     Medline TA:  J Mol Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong, 226001, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thoracoamniotic shunting for fetal pleural effusions using a double-basket shunt.
Next Document:  Protein-associated cation-clusters in aqueous arginine solutions and their effects on protein stabil...