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The Role of C-Choline-PET/CT-Guided Secondary Lymphadenectomy in Patients with PSA Failure after Radical Prostatectomy: Lessons Learned from Eight Cases.
MedLine Citation:
PMID:  21822429     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction. (11)C-choline-PET/CT is a promising technique for detection/restaging of patients with biochemical failure (BF) after curative therapy for prostate cancer (PCA). The aim of this paper was to evaluate the PSA response in patients with BF after radical prostatectomy (RP) who underwent secondary lymphadenectomy (LAD) due to (11)C-choline-PET/CT findings. Material and Methods. Eight patients with BF and positive lymph nodes in (11)C-choline-PET/CT after RP were retrospectively included in the study. Extended LAD until the common iliac arteries was performed in all patients. Results. Six of 8 patients had histologically proven lymph node metastases. Four patients showed an initial PSA reduction after LAD, and in 4 patients the PSA increased. Two of the latter had no histological lymph node metastases. Conclusions. Because 50% of our patients showed an initial PSA response, our data suggest that positive (11)C-choline-PET/CT after RP and BF could help to select patients that could benefit from secondary LAD.
Authors:
Thomas Martini; Roman Mayr; Emanuela Trenti; Salvatore Palermo; Evi Comploj; Armin Pycha; Maria Zywica; Michele Lodde
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Publication Detail:
Type:  Journal Article     Date:  2011-07-31
Journal Detail:
Title:  Advances in urology     Volume:  2012     ISSN:  1687-6377     ISO Abbreviation:  Adv Urol     Publication Date:  2012  
Date Detail:
Created Date:  2011-08-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101476240     Medline TA:  Adv Urol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  601572     Citation Subset:  -    
Affiliation:
Department of Urology, General Hospital of Bolzano, Lorenz Böhler Street 5, 39100 Bolzano, Italy.
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