Document Detail


The Role of Bolus Delay and Dispersion in Predictor Models for Stroke.
MedLine Citation:
PMID:  22343645     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: In combination with diffusion-weighted imaging, perfusion-weighted imaging parameters are hypothesized to detect tissue at risk of infarction in patients with acute stroke. Recent studies have suggested that in addition to perfusion deficits, vascular flow parameters indicating bolus delay and/or dispersion may also contain important predictive information. This work investigates the infarct risk associated with delay/dispersion using multiparametric predictor models. METHODS: Predictor models were developed using specific combinations of perfusion parameters calculated using global arterial input function deconvolution (where perfusion is biased by dispersion), local arterial input function deconvolution (where perfusion has minimal dispersion bias), and parameters approximating bolus delay/dispersion. We also compare predictor models formed using summary parameters (which primarily reflect delay/dispersion). The models were trained on 15 patients with acute stroke imaged at 3 to 6 hours. RESULTS: The global arterial input function models performed significantly better than their local arterial input function counterparts. Furthermore, in a paired comparison, the models including the delay/dispersion parameter performed significantly better than those without. There was no significant difference between the best deconvolution model and the best summary parameter model. CONCLUSIONS: Delay and dispersion information is important to achieve accurate infarct prediction in the acute time window.
Authors:
Lisa Willats; Alan Connelly; Soren Christensen; Geoffrey A Donnan; Stephen M Davis; Fernando Calamante
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  -     ISSN:  1524-4628     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Brain Research Institute and Florey Neuroscience Institutes, Melbourne, Australia; the Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia; and the Departments of Neurology and Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
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