| The Role of Bile Acids in the Neoplastic Progression of Barrett's Esophagus - A Short Representative Overview. | |
| | |
MedLine Citation:
|
PMID: 22965634 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Barrett's esophagus (BE) is an intestinal metaplasia of the distal esophagus in which squamous cells are replaced by a columnar epithelium. It is considered as a premalignant lesion, which can lead to esophageal adenocarcinoma, a very aggressive type of cancer, and can often be found in patients with gastro-esophageal reflux disease (GERD). In spite of the widespread use of acid-suppressing therapy with proton pump inhibitors, the incidence of adenocarcinoma has been steadily rising during the last 30 years. So, it can strongly be suggested that refluxed material other than acid might contribute to the progression of cancer within Barrett's esophagus. Along with gastric acid, bile acids enter the esophagus during an episode of reflux, and bile acids may be important in carcinogenesis. In their refluxates, patients with GERD and BE show high concentrations of the hydrophobic bile salt deoxycholic acid (DCA), which has cytotoxic effects and is able to induce DNA damage in different cell types. Other bile acids, like the hydrophilic urodeoxycholic acid (UDCA), have been therapeutically used to treat cholestatic liver diseases and to prevent colon carcinoma. This article reviews the effects of bile acids and points out new perceptions in the progression of Barrett's-associated carcinogenesis. |
| | |
Authors:
|
S Jürgens; F Meyer; S J Spechler; R Souza |
Related Documents
:
|
8103084 - Time-related loss of glutamine from hippocampal slices and concomitant changes in neuro... 1780024 - The structural and functional heterogeneity of glutamic acid decarboxylase: a review. 11276084 - Identification of new repeating motifs in titin. 17469224 - The influence of manufacture on the free d-amino acid content of cheddar cheese. 18254494 - Characterization of antimicrobial compounds produced by pseudomonas aurantiaca s-1. 23615994 - Jasmonic acid-amino acid conjugation enzyme assays. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-10 |
Journal Detail:
|
Title: Zeitschrift fur Gastroenterologie Volume: 50 ISSN: 1439-7803 ISO Abbreviation: Z Gastroenterol Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0033370 Medline TA: Z Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: 1028-1034 Citation Subset: - |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Dept. of Surgery, Otto-von-Guericke-Universität Magdeburg. |
Vernacular Title:
|
Die Rolle der Gallensäuren in der neoplastischen Progression des Barrett-Ösophagus - eine repräsentative Übersicht. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of Hepatocellular Carcinoma with Sorafenib - Focus on Special Populations and Adverse Even...
Next Document: Disruptive behavior in childhood and socioeconomic position in adulthood: a prospective study over 2...