Document Detail

The Role of Bile Acids in the Neoplastic Progression of Barrett's Esophagus - A Short Representative Overview.
MedLine Citation:
PMID:  22965634     Owner:  NLM     Status:  Publisher    
Barrett's esophagus (BE) is an intestinal metaplasia of the distal esophagus in which squamous cells are replaced by a columnar epithelium. It is considered as a premalignant lesion, which can lead to esophageal adenocarcinoma, a very aggressive type of cancer, and can often be found in patients with gastro-esophageal reflux disease (GERD). In spite of the widespread use of acid-suppressing therapy with proton pump inhibitors, the incidence of adenocarcinoma has been steadily rising during the last 30 years. So, it can strongly be suggested that refluxed material other than acid might contribute to the progression of cancer within Barrett's esophagus. Along with gastric acid, bile acids enter the esophagus during an episode of reflux, and bile acids may be important in carcinogenesis. In their refluxates, patients with GERD and BE show high concentrations of the hydrophobic bile salt deoxycholic acid (DCA), which has cytotoxic effects and is able to induce DNA damage in different cell types. Other bile acids, like the hydrophilic urodeoxycholic acid (UDCA), have been therapeutically used to treat cholestatic liver diseases and to prevent colon carcinoma. This article reviews the effects of bile acids and points out new perceptions in the progression of Barrett's-associated carcinogenesis.
S Jürgens; F Meyer; S J Spechler; R Souza
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-10
Journal Detail:
Title:  Zeitschrift fur Gastroenterologie     Volume:  50     ISSN:  1439-7803     ISO Abbreviation:  Z Gastroenterol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0033370     Medline TA:  Z Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1028-1034     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Dept. of Surgery, Otto-von-Guericke-Universität Magdeburg.
Vernacular Title:
Die Rolle der Gallensäuren in der neoplastischen Progression des Barrett-Ösophagus - eine repräsentative Übersicht.
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