Document Detail


Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.
MedLine Citation:
PMID:  16405654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytotoxic lymphocytes (CL) induce death of their targets by granule exocytosis. During this process, enzymes contained within cytotoxic granules (granzymes) are delivered to the target cell where the enzymes trigger the cell death by cleaving specific substrates. Granzyme B is the only granzyme that has been shown to induce cell death by apoptosis, but the exact pathway by which this is achieved has been the subject of hot debate. Furthermore, several other death-inducing granzymes have been identified; therefore, the exact contribution of granzyme B to CL-induced death is unclear. In this study, we discuss our recent findings on granzyme B-induced cell death and discuss the potential relevance of this pathway to CL-induced death of viral-infected and transformed cells.
Authors:
Nigel J Waterhouse; Karin A Sedelies; Joseph A Trapani
Related Documents :
11586274 - How cells die: apoptosis pathways.
25312824 - Batf3-dependent cd103(+) dendritic cells are major producers of il-12 that drive local ...
12061814 - The effector phase of physiological cell death relies exclusively on the posttranslatio...
20712404 - Regulation of autophagy in the heart: "you only live twice".
21252494 - Modifications of the innate immune system in atopic dermatitis.
9176704 - The physiology of murine germinal center reactions.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunology and cell biology     Volume:  84     ISSN:  0818-9641     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-12     Completed Date:  2006-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Affiliation:
Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. nigel.waterhouse@petermac.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
BH3 Interacting Domain Death Agonist Protein / pharmacology*
Granzymes
Mice
Mitochondrial Membranes / physiology*
Permeability
Serine Endopeptidases / physiology*
T-Lymphocytes, Cytotoxic / immunology,  physiology*
Chemical
Reg. No./Substance:
0/BH3 Interacting Domain Death Agonist Protein; EC 3.4.21.-/Granzymes; EC 3.4.21.-/Gzmb protein, mouse; EC 3.4.21.-/Serine Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Addressing the mysteries of perforin function.
Next Document:  Serpins prevent granzyme-induced death in a species-specific manner.