Document Detail


Role of Bax and Bak in mitochondrial morphogenesis.
MedLine Citation:
PMID:  17035996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bcl-2 family proteins are potent regulators of programmed cell death. Although their intracellular localization to mitochondria and the endoplasmic reticulum has focused research on these organelles, how they function remains unknown. Two members of the Bcl-2 family, Bax and Bak, change intracellular location early in the promotion of apoptosis to concentrate in focal clusters at sites of mitochondrial division. Here we report that in healthy cells Bax or Bak is required for normal fusion of mitochondria into elongated tubules. Bax seems to induce mitochondrial fusion by activating assembly of the large GTPase Mfn2 and changing its submitochondrial distribution and membrane mobility-properties that correlate with different GTP-bound states of Mfn2. Our results show that Bax and Bak regulate mitochondrial dynamics in healthy cells and indicate that Bcl-2 family members may also regulate apoptosis through organelle morphogenesis machineries.
Authors:
Mariusz Karbowski; Kristi L Norris; Megan M Cleland; Seon-Yong Jeong; Richard J Youle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2006-10-01
Journal Detail:
Title:  Nature     Volume:  443     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  658-62     Citation Subset:  IM    
Affiliation:
Biochemistry Section, SNB, NINDS, NIH, Bethesda, Maryland 20892, USA. karbowsm@ninds.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Cells, Cultured
GTP Phosphohydrolases / genetics,  metabolism
Gene Expression
Mice
Mitochondria / physiology*
Morphogenesis
bcl-2 Homologous Antagonist-Killer Protein / metabolism*
bcl-2-Associated X Protein / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/bcl-2 Homologous Antagonist-Killer Protein; 0/bcl-2-Associated X Protein; EC 3.6.1.-/GTP Phosphohydrolases; EC 3.6.1.-/Mfn2 protein, mouse
Comments/Corrections
Comment In:
Nature. 2006 Oct 12;443(7112):646-7   [PMID:  17035992 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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