Document Detail


Role of Anemia in Home Oxygen Therapy in Chronic Obstructive Pulmonary Disease Patients.
MedLine Citation:
PMID:  23567789     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Anemia is a known comorbidity found in chronic obstructive pulmonary disease (COPD) patients. Hypoxemia is common and basically due to ventilation/perfusion (V/Q) mismatch in COPD. Anemia, by decreasing arterial oxygen content, may be a contributing factor for decreased delivery of oxygen to tissues. The objective of this study is to determine if anemia is a factor in qualifying COPD patients for home oxygen therapy. The study was designed as a retrospective, cross-sectional, observational chart review. Patients who were referred for home oxygen therapy evaluation were selected from the computerized patient record system. Demographic data, oxygen saturation at rest and during exercise, pulmonary function test results, hemoglobin level, medications, reason for anemia, comorbid diseases, and smoking status were recorded. The χ tests, independent sample t tests, and logistic regression were used for statistical analysis. Only 356 of total 478 patient referrals had a diagnosis of COPD over a 2-year period. Although 39 of them were excluded, 317 patients were included in the study. The overall rate of anemia was 38% in all COPD patients. Anemia was found significantly more frequent in COPD patients on home oxygen therapy (46%) than those not on home oxygen therapy (18.5%) (P < 0.0001). Mean saturation of peripheral oxygen values were significantly lower in anemic COPD patients both at rest and during exercise (P < 0.0001). Also, in COPD patients, age, Global Initiative for Chronic Obstructive Lung Disease class, smoking status, hemoglobin level, hematocrit, percent of forced expiratory volume in first second, forced expiratory volume in first second/forced vital capacity, residual volume/total lung volume, percent of carbon monoxide diffusion capacity were significantly different between home oxygen therapy and those not on home oxygen therapy (P < 0.05). Multivariate logistic regression showed that anemia remained a strong predictor for long-term oxygen therapy use in COPD patients after adjusting for other significant parameters. Anemic COPD patients are more hypoxic especially during exercise than those who are not anemic. We conclude that anemia is a contributing factor in qualifying COPD patients for home oxygen therapy.
Authors:
Ahmet Sinan Copur; Ashok Fulambarker; Janos Molnar; Rashid Nadeem; Charles McCormack; Aarthi Ganesh; Fayez Kheir; Sara Hamon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-5
Journal Detail:
Title:  American journal of therapeutics     Volume:  -     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Pulmonary Medicine, Captain James A. Lovell Federal Health Care Center, North Chicago, IL; 2Rosalind Franklin University Medical Sciences/Chicago Medical School, North Chicago, IL; 3Department of Physiology and Biophysics, Rosalind Franklin University Medical Sciences/Chicago Medical School, North Chicago, IL; 4Department of Pulmonary and Critical Care, Tulane University, New Orleans, LA; and 5Laboratory of Statistical Genetics, Rockefeller University, New York, NY.
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