| The role of advanced MR imaging findings as biomarkers of traumatic brain injury. | |
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MedLine Citation:
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PMID: 20611045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of traumatic brain injury (TBI) requires proper classification of the pathophysiology. Clinical classifiers and conventional neuroimaging are limited in TBI detection, outcome prediction, and treatment guidance. Advanced magnetic resonance imaging (MRI) techniques such as susceptibility weighted imaging, diffusion tensor imaging, and magnetic resonance spectroscopic imaging are sensitive to microhemorrhages, white matter injury, and abnormal metabolic activities, respectively, in brain injury. In this article, we reviewed these 3 advanced MRI methods and their applications in TBI and report some new findings from our research. These MRI techniques have already demonstrated their potential to improve TBI detection and outcome prediction. As such, they have demonstrated the capacity of serving as a set of biomarkers to reveal the heterogeneous and complex nature of brain injury in a regional and temporal manner. Further longitudinal studies using advanced MRI in a synergistic approach are expected to provide insight in understanding TBI and imaging implications for treatment. |
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Authors:
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Zhifeng Kou; Zhen Wu; Karen A Tong; Barbara Holshouser; Randall R Benson; Jiani Hu; E Mark Haacke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Journal of head trauma rehabilitation Volume: 25 ISSN: 1550-509X ISO Abbreviation: J Head Trauma Rehabil Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702552 Medline TA: J Head Trauma Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 267-82 Citation Subset: IM |
Affiliation:
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Departments of Biomedical Engineering and Radiology, Wayne State University, Detroit, Michigan 48201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Axons
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physiology Biological Markers Brain Hemorrhage, Traumatic / diagnosis, physiopathology Brain Injuries / diagnosis*, physiopathology Diffusion Tensor Imaging* Humans Magnetic Resonance Spectroscopy* Microvessels / injuries Subarachnoid Hemorrhage / diagnosis, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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NIH 62983//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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