| Role of AVP in mediating the altered core temperature response to a simulated open field in pregnant rats. | |
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MedLine Citation:
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PMID: 10409571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Near the term of pregnancy, rats have an attenuated core temperature response on exposure to a novel environment (e.g., a simulated open field) compared with that observed early in pregnancy or in nonpregnant rats. The present experiments were carried out on 26 nonpregnant and 26 pregnant rats to test the hypothesis that arginine vasopressin, functioning as an endogenous antipyretic substance in the central nervous system, mediates this attenuated core temperature response. Exposure to a simulated open field after intracerebroventricular (ICV) vehicle produced a significant increase in core temperature in both nonpregnant and pregnant animals, the magnitude and duration of which were greater in the nonpregnant rats. In nonpregnant rats, exposure to a simulated open field after ICV vasopressin V(1)-receptor antagonist altered the pattern of the core temperature response but not the core temperature index compared with that observed on exposure to a simulated open field after ICV vehicle. In pregnant animals, ICV vasopressin V(1)-receptor antagonist did not alter the core temperature response to a simulated open field compared with that observed after ICV vehicle. Thus our data do not support the hypothesis that a pregnancy-related activation of arginine vasopressin attenuates the core temperature response to a simulated open field in rats near the term of pregnancy. |
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Authors:
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P A Tang; J E Fewell; H L Eliason |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 87 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-27 Completed Date: 1999-08-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 170-4 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada T2N 4N1. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / analogs & derivatives, pharmacology, physiology* Body Temperature Regulation / drug effects, physiology* Environment Female Fever / etiology, physiopathology Hormone Antagonists / pharmacology Pregnancy Pregnancy Complications / physiopathology Pregnancy, Animal / physiology* Rats Rats, Sprague-Dawley Receptors, Vasopressin / antagonists & inhibitors Stress, Physiological / complications, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Hormone Antagonists; 0/Receptors, Vasopressin; 0/vasopressin, 1-(2-mercapto-2,2-(cyclopentamethylene)propionic acid)-2-(O-methyl)Tyr-8-Arg-; 113-79-1/Arginine Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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