Document Detail

Role of ART in imprinting disorders.
MedLine Citation:
PMID:  22549709     Owner:  NLM     Status:  MEDLINE    
Assisted reproductive technologies (ART) offer revolutionary infertility treatments for millions of childless couples around the world. Currently, ART accounts for 1 to 3% of annual births in industrialized countries and continues to expand rapidly. Except for an increased incidence of premature births, these technologies are considered safe. However, new evidence published during the past decade has suggested an increased incidence of imprinting disorders in children conceived by ART. Specifically, an increased risk was reported for Beckwith-Wiedemann syndrome (BWS), Angelman syndrome (AS), Silver-Russell syndrome, and retinoblastoma. In contrast, some studies have found no association between ART and BWS, AS, Prader-Willi syndrome, transient neonatal diabetes mellitus, and retinoblastoma. The variability in ART protocols and the rarity of imprinting disorders complicate determining the causative relationship between ART and an increased incidence of imprinting disorders. Nevertheless, compelling experimental data from animal studies also suggest a link between increased imprinting disorders and ART. Further comprehensive, appropriately powered studies are needed to better address the magnitude of the risk for ART-associated imprinting disorders. Large longitudinal studies are particularly critical to evaluate long-term effects of ART not only during the perinatal period but also into adulthood. An important consideration is to determine if the implicated association between ART and imprinting disorders is actually related to the procedures or to infertility itself.
Ali Eroglu; Lawrence C Layman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-27
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  30     ISSN:  1526-4564     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-09-10     Revised Date:  2013-12-06    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-104     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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MeSH Terms
Abnormalities, Multiple / epidemiology,  etiology*
DNA Methylation
Gene Expression Regulation, Developmental
Genomic Imprinting*
Histones / metabolism
Infertility / complications,  etiology
Pregnancy Complications / epidemiology,  etiology
RNA, Untranslated / metabolism
Reproductive Techniques, Assisted / adverse effects*
Grant Support
Reg. No./Substance:
0/Histones; 0/RNA, Untranslated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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