Document Detail


Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: a systematic review and meta-analysis.
MedLine Citation:
PMID:  15849829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To identify the role of alpha-fetoprotein (AFP) mRNA expression in peripheral blood one week after surgery as a predictor for recurrence of hepatocellular carcinoma (HCC). METHODS: Published studies fulfilling the selection criteria were identified by searching several databases online. After a methodology assessment using a quality scale designed by European Lung Cancer Working Party, data in each research were aggregated by means of meta-analysis. RESULTS: Altogether 368 cases were included in the 9 selected studies, which fulfilled the selection criteria. The quality scores ranged from 35% to 84% with a median score of 55%. The 'design' subscore had the lowest median value (38%). By aggregating the data, a high chi2 value (77.576) was presented. The fail-safe number was 136 and 64 for P = 0.05 and 0.01, respectively. CONCLUSION: AFP mRNA expression in peripheral blood 1 wk after surgery correlated with the recurrence of HCC and was a good predictor for tumor recurrence.
Authors:
Xiang Ding; Lian-Yue Yang; Geng-Wen Huang; Jian-Qing Yang; He-Li Liu; Wei Wang; Ji-Xiang Peng; Jie-Quan Yang; Yi-Ming Tao; Zhi-Gang Chang; Xiu-Shou Ling
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2656-61     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. lianyueyang@hotmail.com.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Hepatocellular / physiopathology*,  surgery
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms / physiopathology*,  surgery
Neoplasm Recurrence, Local / diagnosis,  physiopathology*
Predictive Value of Tests
RNA, Messenger
Tumor Markers, Biological
alpha-Fetoproteins / genetics*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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