Document Detail

Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: a systematic review and meta-analysis.
MedLine Citation:
PMID:  15849829     Owner:  NLM     Status:  MEDLINE    
AIM: To identify the role of alpha-fetoprotein (AFP) mRNA expression in peripheral blood one week after surgery as a predictor for recurrence of hepatocellular carcinoma (HCC). METHODS: Published studies fulfilling the selection criteria were identified by searching several databases online. After a methodology assessment using a quality scale designed by European Lung Cancer Working Party, data in each research were aggregated by means of meta-analysis. RESULTS: Altogether 368 cases were included in the 9 selected studies, which fulfilled the selection criteria. The quality scores ranged from 35% to 84% with a median score of 55%. The 'design' subscore had the lowest median value (38%). By aggregating the data, a high chi2 value (77.576) was presented. The fail-safe number was 136 and 64 for P = 0.05 and 0.01, respectively. CONCLUSION: AFP mRNA expression in peripheral blood 1 wk after surgery correlated with the recurrence of HCC and was a good predictor for tumor recurrence.
Xiang Ding; Lian-Yue Yang; Geng-Wen Huang; Jian-Qing Yang; He-Li Liu; Wei Wang; Ji-Xiang Peng; Jie-Quan Yang; Yi-Ming Tao; Zhi-Gang Chang; Xiu-Shou Ling
Related Documents :
8387439 - A patient with hepatocellular carcinoma who underwent resection of the primary lesion 1...
18333159 - Staging systems in hepatocellular carcinoma.
17899289 - Preoperative portal vein embolization and surgical resection in patients with hepatocel...
8751199 - Early recurrence after surgery of hepatocellular carcinoma.
20815419 - Stereotactic radiotherapy of hepatocellular carcinoma: preliminary results.
19926229 - Combination of transarterial chemoembolization and three-dimensional conformal radiothe...
24524969 - Analysis of molecular cytogenetic changes in metastatic renal cell carcinoma in the set...
17065139 - Late response to radiochemotherapy in pediatric glioblastoma: report on two patients tr...
7397619 - Response to hormonal therapy as a prognostic factor for metastatic breast cancer treate...
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2656-61     Citation Subset:  IM    
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Hepatocellular / physiopathology*,  surgery
Gene Expression Regulation, Neoplastic
Liver Neoplasms / physiopathology*,  surgery
Neoplasm Recurrence, Local / diagnosis,  physiopathology*
Predictive Value of Tests
RNA, Messenger
Tumor Markers, Biological
alpha-Fetoproteins / genetics*
Reg. No./Substance:
0/RNA, Messenger; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Transfection of apoptosis related gene Fas ligand in human hepatocellular carcinoma cells and its si...
Next Document:  Dynamical changing patterns of glycogen and enzyme histochemical activities in rat liver graft under...