Document Detail

Role of ACh-GABA cotransmission in detecting image motion and motion direction.
MedLine Citation:
PMID:  21172616     Owner:  NLM     Status:  MEDLINE    
Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, suggesting the two transmitters were released from different vesicle populations. Despite the symmetric cholinergic connection, the light-evoked cholinergic input to a DSGC, detected at both light onset and offset, was motion- and direction-sensitive. This input was facilitated by two-spot apparent motion in the preferred direction but supressed in the null direction, presumably by a GABAergic mechanism. The results revealed a high level of synaptic intricacy in the starburst circuit and suggested differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.
Seunghoon Lee; Kyongmin Kim; Z Jimmy Zhou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  68     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-01-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1159-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Acetylcholine / physiology*
Amacrine Cells / physiology
Motion Perception / physiology*
Photic Stimulation / methods
Retina / physiology*
Synapses / physiology
Synaptic Transmission / physiology*
gamma-Aminobutyric Acid / physiology*
Grant Support
P30 EY000785/EY/NEI NIH HHS; R01 EY010894/EY/NEI NIH HHS; R01 EY010894-16/EY/NEI NIH HHS; R01 EY017353/EY/NEI NIH HHS; R01 EY017353-06/EY/NEI NIH HHS; R01EY017353/EY/NEI NIH HHS; R01EY10894/EY/NEI NIH HHS
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; N9YNS0M02X/Acetylcholine

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