Document Detail


Role of ACh-GABA cotransmission in detecting image motion and motion direction.
MedLine Citation:
PMID:  21172616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, suggesting the two transmitters were released from different vesicle populations. Despite the symmetric cholinergic connection, the light-evoked cholinergic input to a DSGC, detected at both light onset and offset, was motion- and direction-sensitive. This input was facilitated by two-spot apparent motion in the preferred direction but supressed in the null direction, presumably by a GABAergic mechanism. The results revealed a high level of synaptic intricacy in the starburst circuit and suggested differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.
Authors:
Seunghoon Lee; Kyongmin Kim; Z Jimmy Zhou
Related Documents :
10367966 - Balanced interactions in ganglion-cell receptive fields.
7529586 - Interaction of apical and basal membrane ion channels underlies electroreception in amp...
9447716 - Sensitivity and response dynamics of elasmobranch electrosensory primary afferent neuro...
17287436 - Limits of linear rate coding of dynamic stimuli by electroreceptor afferents.
14553826 - Cholinergic atrial fibrillation: i(k,ach) gradients determine unequal left/right atrial...
21929806 - Reduced thoracolumbar fascia shear strain in human chronic low back pain.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  68     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-01-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1159-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholine / physiology*
Amacrine Cells / physiology
Animals
Motion Perception / physiology*
Photic Stimulation / methods
Rabbits
Retina / physiology*
Synapses / physiology
Synaptic Transmission / physiology*
gamma-Aminobutyric Acid / physiology*
Grant Support
ID/Acronym/Agency:
P30 EY000785/EY/NEI NIH HHS; R01 EY010894/EY/NEI NIH HHS; R01 EY010894-16/EY/NEI NIH HHS; R01 EY017353/EY/NEI NIH HHS; R01 EY017353-06/EY/NEI NIH HHS; R01EY017353/EY/NEI NIH HHS; R01EY10894/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; N9YNS0M02X/Acetylcholine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Local presynaptic activity gates homeostatic changes in presynaptic function driven by dendritic BDN...
Next Document:  Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegan...