Role of ACh-GABA cotransmission in detecting image motion and motion direction. | |
MedLine Citation:
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PMID: 21172616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, suggesting the two transmitters were released from different vesicle populations. Despite the symmetric cholinergic connection, the light-evoked cholinergic input to a DSGC, detected at both light onset and offset, was motion- and direction-sensitive. This input was facilitated by two-spot apparent motion in the preferred direction but supressed in the null direction, presumably by a GABAergic mechanism. The results revealed a high level of synaptic intricacy in the starburst circuit and suggested differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity. |
Authors:
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Seunghoon Lee; Kyongmin Kim; Z Jimmy Zhou |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 68 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-21 Completed Date: 2011-01-19 Revised Date: 2014-09-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 1159-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Export Citation:
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MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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physiology* Amacrine Cells / physiology Animals Motion Perception / physiology* Photic Stimulation / methods Rabbits Retina / physiology* Synapses / physiology Synaptic Transmission / physiology* gamma-Aminobutyric Acid / physiology* |
Grant Support | |
ID/Acronym/Agency:
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P30 EY000785/EY/NEI NIH HHS; R01 EY010894/EY/NEI NIH HHS; R01 EY010894-16/EY/NEI NIH HHS; R01 EY017353/EY/NEI NIH HHS; R01 EY017353-06/EY/NEI NIH HHS; R01EY017353/EY/NEI NIH HHS; R01EY10894/EY/NEI NIH HHS |
Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid; N9YNS0M02X/Acetylcholine |
Comments/Corrections |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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