Document Detail

Role of 99mTc-disofenin in duodenal and gastric aspirates in the evaluation of persistent neonatal cholestasis.
MedLine Citation:
PMID:  2695610     Owner:  NLM     Status:  MEDLINE    
A prospective study was undertaken on 49 infants with prolonged neonatal cholestasis to determine whether the specificity, sensitivity, and accuracy of 99mTc-disofenin scintigraphy can be improved by performing simultaneous radioactivity measurements on duodenal and gastric aspirates along with routine imaging. Specificity of routine scintigraphy was improved by this modification from 45.7 to 76.4%. Accuracy of the test was also superior in improving from 55% with routine scintigraphy to 78.4% by counting additional radioactivity on both duodenal and gastric aspirates. We suggest that this modified technique be applied in the evaluation of infants with conjugated hyperbilirubinemia so that invasive procedures such as open liver biopsy and operative cholangiogram may be avoided.
V Tolia; L Kuhns; R S Dubois
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  9     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-03-29     Completed Date:  1990-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  426-30     Citation Subset:  IM    
G.I. Procedure Unit, Children's Hospital of Michigan, Wayne State University, Detroit 48201.
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MeSH Terms
Duodenum / radionuclide imaging*
Gastric Juice / radionuclide imaging*
Imino Acids / diagnostic use
Infant, Newborn
Intestinal Secretions / radionuclide imaging*
Jaundice, Neonatal / radionuclide imaging*
Organotechnetium Compounds / diagnostic use
Prospective Studies
Sensitivity and Specificity
Technetium Tc 99m Disofenin
Reg. No./Substance:
0/Imino Acids; 0/Organotechnetium Compounds; 0/Technetium Tc 99m Disofenin
Comment In:
J Pediatr Gastroenterol Nutr. 1990 Oct;11(3):422   [PMID:  2246730 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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