| Role of (68)Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours. | |
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MedLine Citation:
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PMID: 21750886 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the present study was to evaluate the role of (68)Ga-DOTA(0)-Phe(1)-Tyr(3)-octreotide ((68)Ga-DOTATOC) positron emission tomography computed tomography (PET-CT) for detection and staging of pancreatic neuroendocrine tumours (NETs). METHODS: Twenty patients with clinically suspected and/or histopathologically proven pancreatic NET underwent (68)Ga-DOTATOC PET-CT imaging for staging and /or localisation of primary lesion. They also underwent contrast enhanced CT (CECT) and 8 patients underwent (18)F-FDG PET-CT. SUVmax of primary and metastatic lesions were measured. Results were verified with histopathology for primary tumour and with clinical follow up/MRI and /or biopsy for metastatic disease. Results of (68)Ga-DOTATOC PET-CT were compared to CECT and (18)F-FDG PET-CT. RESULTS: (68)Ga-DOTATOC PET-CT correctly localised primary in all 20, CECT in 15 and (18)F-FDG PET-CT in 2 patients. (68)Ga-DOTATOC PET-CT demonstrated metastases in 13 patients, CECT in 7 and (18)F-FDG PET-CT in 2. (68)Ga-DOTATOC PET-CT emerged as the best investigation with 100% sensitivity and PPV for detecting primary tumour and metastatic disease. The detection rate of CECT was lower than (68)Ga-DOTATOC PET-CT, both for primary tumour (20vs.15) or metastatic disease (13vs.7). (18)F-FDG PET-CT performed poorly for primary and metastasis. CONCLUSION: Ga-DOTATOC PET-CT is a very useful imaging investigation for diagnosing and staging pancreatic NET. |
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Authors:
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Rakesh Kumar; Punit Sharma; Pramod Garg; Sellam Karunanithi; Niraj Naswa; Raju Sharma; Sanjay Thulkar; Sneh Lata; Arun Malhotra |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-13 |
Journal Detail:
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Title: European radiology Volume: - ISSN: 1432-1084 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (east), AIIMS Campus, New Delhi, 110029, India, rkphulia@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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