Document Detail


Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists.
MedLine Citation:
PMID:  12646419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The 5-HT1B/D receptor agonist sumatriptan has been proposed to treat dyspeptic symptoms, because it facilitates gastric accommodation. It is unknown whether stimulation of 5-HT1B/D receptors is involved. Thus, in four conscious dogs, we compared the effects of sumatriptan alone or combined with N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1-biphenyl]-4-carboxamide hydrocloride (GR-127935), N-[3-[3 (dimethylamino)-ethoxy]-4-methoxyphenyl]-2'-[methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)]-[1,1-biphenyl]-4-carboxamide hydrocloride (SB-216641 hydrochloride), or 3-[4-(4-chloro-phenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride (BRL-15572 hydrochloride) (respectively, nonselective 5-HT1B/D, selective 5-HT1B, and selective 5-HT1D receptor antagonists) on gastric accommodation to isobaric distensions performed with a barostat. An exponential and a linear model were used to fit the pressure-volume relationship. An exponential equation fitted the data better than a linear equation. Sumatriptan (800 nmol/kg iv) induced an immediate gastric relaxation (Deltavolume: 112 +/- 44 ml, P < 0.05). After sumatriptan, the pressure-volume curve was shifted toward significantly higher volumes. This effect was fully reversed by GR-127935 or SB-216641 but not by BRL-15572. In conclusion, 5-HT1B receptors seem to play an important role in modulating gastric accommodation to a distending stimulus. An exponential model for pressure-volume curves fits well with the concept of gastric adaptive relaxation.
Authors:
Fabrizio De Ponti; Francesca Crema; Elisabetta Moro; Giuseppe Nardelli; Gianmario Frigo; Antonio Crema
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-03-19
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  285     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G96-104     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126 Bologna, Italy. deponti@biocfarm.unibo.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Benzamides / pharmacology
Bethanechol / pharmacology
Biphenyl Compounds / pharmacology
Dogs
Enzyme Inhibitors / pharmacology
Female
Gastric Emptying / drug effects,  physiology*
NG-Nitroarginine Methyl Ester / pharmacology
Oxadiazoles / pharmacology*
Parasympatholytics / pharmacology
Parasympathomimetics / pharmacology
Piperazines / pharmacology*
Pressure
Receptor, Serotonin, 5-HT1B
Receptor, Serotonin, 5-HT1D
Receptors, Serotonin / metabolism*
Serotonin Agonists / pharmacology*
Serotonin Antagonists / pharmacology*
Stomach / innervation,  physiology
Sumatriptan / pharmacology*
Vagus Nerve / physiology
Chemical
Reg. No./Substance:
0/BRL 15572; 0/Benzamides; 0/Biphenyl Compounds; 0/Enzyme Inhibitors; 0/N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide; 0/Oxadiazoles; 0/Parasympatholytics; 0/Parasympathomimetics; 0/Piperazines; 0/Receptor, Serotonin, 5-HT1B; 0/Receptor, Serotonin, 5-HT1D; 0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Serotonin Antagonists; 103628-46-2/Sumatriptan; 148672-13-3/GR 127935; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-55-8/Atropine; 674-38-4/Bethanechol

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