| Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. | |
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MedLine Citation:
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PMID: 12646419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 5-HT1B/D receptor agonist sumatriptan has been proposed to treat dyspeptic symptoms, because it facilitates gastric accommodation. It is unknown whether stimulation of 5-HT1B/D receptors is involved. Thus, in four conscious dogs, we compared the effects of sumatriptan alone or combined with N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1-biphenyl]-4-carboxamide hydrocloride (GR-127935), N-[3-[3 (dimethylamino)-ethoxy]-4-methoxyphenyl]-2'-[methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)]-[1,1-biphenyl]-4-carboxamide hydrocloride (SB-216641 hydrochloride), or 3-[4-(4-chloro-phenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride (BRL-15572 hydrochloride) (respectively, nonselective 5-HT1B/D, selective 5-HT1B, and selective 5-HT1D receptor antagonists) on gastric accommodation to isobaric distensions performed with a barostat. An exponential and a linear model were used to fit the pressure-volume relationship. An exponential equation fitted the data better than a linear equation. Sumatriptan (800 nmol/kg iv) induced an immediate gastric relaxation (Deltavolume: 112 +/- 44 ml, P < 0.05). After sumatriptan, the pressure-volume curve was shifted toward significantly higher volumes. This effect was fully reversed by GR-127935 or SB-216641 but not by BRL-15572. In conclusion, 5-HT1B receptors seem to play an important role in modulating gastric accommodation to a distending stimulus. An exponential model for pressure-volume curves fits well with the concept of gastric adaptive relaxation. |
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Authors:
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Fabrizio De Ponti; Francesca Crema; Elisabetta Moro; Giuseppe Nardelli; Gianmario Frigo; Antonio Crema |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-03-19 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 285 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-11 Completed Date: 2003-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G96-104 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126 Bologna, Italy. deponti@biocfarm.unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Benzamides / pharmacology Bethanechol / pharmacology Biphenyl Compounds / pharmacology Dogs Enzyme Inhibitors / pharmacology Female Gastric Emptying / drug effects, physiology* NG-Nitroarginine Methyl Ester / pharmacology Oxadiazoles / pharmacology* Parasympatholytics / pharmacology Parasympathomimetics / pharmacology Piperazines / pharmacology* Pressure Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin / metabolism* Serotonin Agonists / pharmacology* Serotonin Antagonists / pharmacology* Stomach / innervation, physiology Sumatriptan / pharmacology* Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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0/BRL 15572; 0/Benzamides; 0/Biphenyl Compounds; 0/Enzyme Inhibitors; 0/N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide; 0/Oxadiazoles; 0/Parasympatholytics; 0/Parasympathomimetics; 0/Piperazines; 0/Receptor, Serotonin, 5-HT1B; 0/Receptor, Serotonin, 5-HT1D; 0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Serotonin Antagonists; 103628-46-2/Sumatriptan; 148672-13-3/GR 127935; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-55-8/Atropine; 674-38-4/Bethanechol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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