Document Detail


Role of 5-lipoxygenase pathway in the pathophysiology of the aortic stenosis.
MedLine Citation:
PMID:  21809967     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Evaluation of: Nagy E, Andersson DC, Caidahl K et al. Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. Circulation DOI: 10.1161/CIRCULATIONAHA.110.966846 (2011) (Epub ahead of print). Understanding the exact pathophysiological mechanism of degenerative aortic stenosis is important in order to develop new treatment modalities and prevent progression of the disease. Recently, most of the inflammatory markers in association with aortic stenosis have been described. The authors of the paper under evaluation investigate the effects of the 5-lipoxygenase pathway on aortic valve stenosis and correlation with severity of stenosis. In this article, we suggest that the 5-lipoxygenase pathway is one of the possible factors in the development of aortic stenosis.
Authors:
Ramazan Akdemir; M Bulent Vatan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  9     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  853-5     Citation Subset:  IM    
Affiliation:
Sakarya University, Medical Faculty, Department of Cardiology, Sakarya, Turkey. rakdemir@yahoo.com.
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