| Role of 5-hydroxytryptamine in ketamine-induced hypothermia in the rat. | |
| | |
MedLine Citation:
|
PMID: 4274691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Intraperitoneal injection of graded doses of ketamine produced a dose-dependent fall in body temperature of rats. Similarly, intracerebral injection of much smaller doses produced hypothermia.2. Pretreatment of the rats with p-chlorophenylalanine (PCPA) greatly attenuated the hypothermic response to ketamine whereas the intraperitoneal injection of 5-hydroxytryptophan in PCPA-treated rats restored the hypothermic effect of ketamine.3. Depletion of the brain monoamines by reserpine completely prevented the ketamine-induced hypothermia. Treatment with sodium diethyldithiocarbamate (DEDTC), however, did not modify the hypothermic effect of ketamine.4. Pretreatment of the rats with pargyline potentiated the ketamine-induced hypothermia.5. Depletion of brain monoamines by reserpine in combination with inhibition of noradrenaline biosynthesis (DEDTC) resulted in a long lasting fall in temperature which was not modified by ketamine.6. When the ambient temperature was raised from 26 degrees C to 32 degrees C, ketamine-induced hypothermia was much reduced and superimposed on a hyperthermia which occurred in all animals.7. It is concluded that ketamine produces hypothermia in rats possibly through the release of 5-hydroxytryptamine in the hypothalamus and that this effect is similar in some respects to that produced by morphine in non-tolerant rats. |
| | |
Authors:
|
I Fahim; M Ismail; O H Osman |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of pharmacology Volume: 48 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1973 Aug |
Date Detail:
|
Created Date: 1974-06-19 Completed Date: 1974-06-19 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 570-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
5-Hydroxytryptophan
/
pharmacology Animals Body Temperature / drug effects Brain / drug effects Dose-Response Relationship, Drug Ergotamine / pharmacology Female Fenclonine / pharmacology Hypothalamus / drug effects Hypothermia / chemically induced* Injections, Intraperitoneal Injections, Subcutaneous Ketamine / antagonists & inhibitors, pharmacology* Methysergide / pharmacology Norepinephrine / biosynthesis Pargyline / pharmacology Rats Reserpine / pharmacology Serotonin / secretion* Temperature Thiocarbamates / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Thiocarbamates; 113-15-5/Ergotamine; 361-37-5/Methysergide; 50-55-5/Reserpine; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 555-57-7/Pargyline; 56-69-9/5-Hydroxytryptophan; 6740-88-1/Ketamine; 7424-00-2/Fenclonine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Base ratio and deoxyribonucleic acid homology studies of six Staphylococcus aureus typing bacterioph...
Next Document: Localization of transport adenosine triphosphatase in rat cornea.