Document Detail

Role of 5-HT1-7 receptors in short- and long-term memory for an autoshaping task: intrahippocampal manipulations.
MedLine Citation:
PMID:  17368430     Owner:  NLM     Status:  MEDLINE    
It was previously reported that brain areas containing serotonin (5-hydroxytryptamine, 5-HT) receptors mediate memory consolidation as well as short (STM)- and long-term memory (LTM). Here the effects of systemic and intrahippocampal administration of 5-HT agonists and antagonists on an autoshaping learning task were explored, which requires hippocampal translation and transduction as well as 5-HT receptors expression. As previously reported ketamine (glutamatergic antagonist) and two well-known amnesic drugs, scopolamine (cholinergic antagonist) and dizocilpine (NMDA antagonist) impaired STM but not LTM; dizocilpine even improved the latter. Since ketamine produces hallucinations and impairs memory in humans, we address the question if well-known antipsychotic haloperidol and clozapine might affect STM deficit. Indeed, systemic administration of clozapine<haloperidol reversed the ketamine-STM deficit. Considering that clozapine and haloperidol are antagonists for dopaminergic D2 and 5-HT(1A/2A/6/7) receptors, systemic and intrahippocampal administration of 5-HT drugs were further explored. The ketamine STM-induced deficit was blocked by 8-OHDPAT (5-HT(1A/7) agonist) and SB-399885 (a 5-HT(6) antagonist) but not by 5-HT(1B), 5-HT(2) and 5-HT(7) antagonists, thus implicating 5-HT(1A/7) and 5-HT(6) receptors. These data also suggest that ketamine (at 10 mg/kg) represents a reliable pharmacological tool to explore memory deficits related to hippocampus and schizophrenia.
Gustavo Liy-Salmeron; Alfredo Meneses
Publication Detail:
Type:  Journal Article     Date:  2007-02-08
Journal Detail:
Title:  Brain research     Volume:  1147     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  140-7     Citation Subset:  IM    
Departamento de Farmacobiología, CINVESTAV-IPN, Tenorios 235, Granjas Coapa 14330, México.
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MeSH Terms
Analysis of Variance
Antipsychotic Agents / pharmacology
Conditioning, Classical / drug effects,  physiology*
Drug Interactions
Hippocampus / drug effects,  physiology*
Memory / drug effects,  physiology*
Neurotransmitter Agents / pharmacology
Rats, Wistar
Receptors, Serotonin / classification,  drug effects,  physiology*
Serotonin Agents / pharmacology
Reg. No./Substance:
0/Antipsychotic Agents; 0/Neurotransmitter Agents; 0/Receptors, Serotonin; 0/Serotonin Agents

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