| Role of 18F-FDG PET/CT in management of high-grade salivary gland malignancies. | |
| | |
MedLine Citation:
|
PMID: 17631549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of 18F-FDG PET/CT for planning the treatment of high-grade salivary gland malignancies was investigated and was compared with that with using contrast-enhanced CT. METHODS: The subjects chosen for the study had high-grade cancer of the salivary gland, as confirmed by surgical pathology. The diagnostic values from 37 CT and PET/CT scans of 33 subjects were compared. The ability to predict the extent of the disease was compared by performing a subsite-based analysis for the primary lesions and a level-by-level analysis for the neck node levels as well as for the final TNM staging. The surgical pathology (67.6%) and clinical follow-up examinations (32.4%) were used as the reference standards. Furthermore, the changes made in each subject's care, based on a PET/CT examination, were compared with the treatment received without using the PET/CT data. RESULTS: Using a primary subsite-based analysis, the diagnostic accuracy for predicting the pathologic tumor extent was significantly higher for PET/CT (91.0%) compared with that using CT alone (70.1%, P < 0.001). For the neck nodes on a level-by-level analysis, the metastasis could be predicted more accurately on the basis of a PET/CT examination (97.6%) than with using only CT (86.0%, P = 0.01). PET/CT was also far superior to CT in terms of the TNM staging (83.7% vs. 62.1%, P = 0.03). For 43.2% of the subjects, changes in the clinical decision making were made as a result of the PET/CT scan data over what was previously determined by using the CT scans alone. CONCLUSION: PET/CT provides more accurate diagnostic information for the evaluation of high-grade salivary cancer than does CT and it has a major impact on making treatment decisions for patients with a high-grade salivary malignancy. |
| | |
Authors:
|
Han-Sin Jeong; Man Ki Chung; Young-Ik Son; Joon Young Choi; Hyung Jin Kim; Young Hyeh Ko; Chung-Hwan Baek |
Related Documents
:
|
15299049 - Retrospective digital image fusion of multidetector ct and 18f-fdg pet: clinical value ... 16538409 - 18f-2-fluoro-2-deoxy-d-glucose positron emission tomography scanning affects surgical m... 18465129 - Detection of bone metastases in patients with prostate cancer by 18f fluorocholine and ... 9257149 - Preoperative and postoperative imaging for colorectal cancer. 19890899 - Noninvasive imaging surrogate of angiogenesis in osteosarcoma. 19692289 - Advances in imaging in the work-up of head and neck cancer patients. 11216519 - 64cu-teta-octreotide as a pet imaging agent for patients with neuroendocrine tumors. 17411099 - A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging. 14676719 - Imaging features of brain tuberculoma in tanzania: case report and literature review. |
Publication Detail:
|
Type: Journal Article Date: 2007-07-13 |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 48 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-08-03 Completed Date: 2007-09-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1237-44 Citation Subset: IM |
Affiliation:
|
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Positron-Emission Tomography / methods* Radiographic Image Enhancement Radiopharmaceuticals / diagnostic use* Salivary Gland Neoplasms / diagnosis*, therapy Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: (111)In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): an Auger...
Next Document: Nuclear uptake and dosimetry of 64Cu-labeled chelator somatostatin conjugates in an SSTr2-transfecte...