Document Detail


Role of [(18)F]-FDG-PET/MDCT in evaluating early response in patients with Hodgkin's lymphoma.
MedLine Citation:
PMID:  22327919     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The authors evaluated the prognostic role of 18-fluoro-fluorodeoxyglucose positron emission tomography/multidetector computed tomography ([(18)F]-FDG PET/MDCT) in treating patients with Hodgkin's lymphoma (HL). MATERIALS AND METHODS: We retrospectively evaluated 132 patients with HL studied with PET/MDCT before the start of chemotherapy (CTX) for staging purposes and again after two CTX cycles with [doxorubicin (Adriblastin), bleomycin, vinblastine, dacarbazine (ABVD_] (interim PET/MDCT), at least 30 days after the end of the last CTX cycle and/or 3 months after the end of radiotherapy, if delivered (final PET-MDCT). RESULTS: Interim PET-MDCT was negative in 104/132 patients (79%), and their final PET-MDCT showed complete remission in 102/104 (98%) of cases, with disease recurrence/persistence in two (2%). In the remaining 28 (21%) patients, interim PET-MDCT revealed an early response in 68% of cases and chemoresistance with disease progression in 32% of cases; in these 28 patients, final PET-MDCT showed a lack of response to treatment in 43% of cases (43%) and complete remission in 57% of cases. Statistical analysis of these data showed that interim PET-MDCT had a negative predictive value of 98% and a positive predictive value of 42%, with values of sensitivity, specificity and diagnostic accuracy of 85.7%, 86.4% and 86.4%, respectively. CONCLUSIONS: Interim PET-MDCT has a reliable prognostic role in diagnosis and treatment of patients with HL, as it helps predict which patients are more likely to achieve a complete response at the end of treatment. PET/MDCT may also lead to a change in treatment, with reduced treatment-related toxic effects and significantly reduced total costs.
Authors:
A Orlacchio; O Schillaci; E Gaspari; F Della Gatta; R Danieli; F Bolacchi; C Ragano Caracciolo; A Mancini; G Simonetti
Related Documents :
19396819 - Patterns of care in a population-based sample of soft tissue sarcoma patients in the un...
22275979 - Poorly differentiated synovial sarcoma of the vagina: a case report and a clinical lite...
23828279 - Retrospective study of pemetrexed as salvage therapy for central nervous system lymphoma.
22410029 - Investigation of histological vascular invasion from preoperative evaluation in patient...
22778939 - Is there a role for postmastectomy radiation therapy in ductal carcinoma in situ?
22783359 - Should we still use camitta's criteria for severe aplastic anemia?
3731129 - Phase i and pharmacological study of vinblastine by prolonged continuous infusion.
23729239 - Sentinel node biopsy as an alternative to elective neck dissection for staging of early...
15848689 - University of wisconsin solution versus celsior solution in clinical pancreas transplan...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-10
Journal Detail:
Title:  La Radiologia medica     Volume:  -     ISSN:  1826-6983     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177625     Medline TA:  Radiol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, Policlinico Universitario "Tor Vergata", Via Oxford 81, 00133, Roma, Italy, aorlacchio@uniroma2.it.
Vernacular Title:
Ruolo della (18)F-FDG PET/TCms nella valutazione della risposta precoce al trattamento del linfoma di Hodgkin.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ultrasound findings in dual kidney transplantation.
Next Document:  Comparison of cryoplasty and conventional angioplasty for treating stenotic-occlusive lesions of the...