| Role of 18F-FDG PET in detecting primary site in the patient with primary unknown carcinoma. | |
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MedLine Citation:
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PMID: 20814690 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The aim of this study was to verify the effectiveness of positron emission tomography (PET) in detecting primary sites in carcinoma of unknown primary (CUP) patients. In this study, CUP represented a group of heterogeneous tumors that shared the clinical manifestation of metastatic carcinoma with no obvious primary site at the time of first diagnosis, which included clinical investigations, computed tomography, magnetic resonance imaging and panendoscopy. We reviewed the records of 24 patients with CUP between January 1995 and December 2009. The patients who demonstrated additional tracer uptake sites other than previously known metastatic lesions by PET scan were done direct biopsies for the sites of accumulation. Patients who had a negative PET scan or for whom the primary site could not be identified by direct biopsies underwent examination under anesthesia of the at-risk occult tumor sites. PET scan demonstrated focal accumulation suspicious for primary tumor in 12 (50.0%) of 24 patients: tonsil 5, nasopharynx 3, hypopharynx 1, tongue 1, larynx 1, and maxillary sinus 1. A subsequent biopsy of these sites revealed primary cancer in 9 (37.5%) of 24 patients: tonsil 5, nasopharynx 1, hypopharynx 1, tongue 1, and maxillary sinus 1. In the remaining three patients, no malignant cells were found by the biopsy of the accumulated area: nasopharynx 2, larynx 1. PET scans increase the yield of primary tumor by 37.5%. The sensitivity, specificity for PET scan were 80.8, 76.9%, respectively. PET scanning is useful in detecting primary cancer of CUP patients. |
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Authors:
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Kenichiro Yabuki; Mamoru Tsukuda; Choichi Horiuchi; Takahide Taguchi; Goshi Nishimura |
Publication Detail:
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Type: Journal Article Date: 2010-09-03 |
Journal Detail:
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Title: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery Volume: 267 ISSN: 1434-4726 ISO Abbreviation: Eur Arch Otorhinolaryngol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002937 Medline TA: Eur Arch Otorhinolaryngol Country: Germany |
Other Details:
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Languages: eng Pagination: 1785-92 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, and Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, 3-9 Fukuura, Yokohama, Kanazawa 236-0004, Japan. kenichirouy@jadecom.jp |
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| Comments/Corrections | |
Comment In:
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Eur Arch Otorhinolaryngol. 2010 Nov;267(11):1653-5
[PMID:
20827553
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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