| Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy. | |
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MedLine Citation:
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PMID: 20544323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the utility of (11)C-choline PET/CT in the restaging of prostate cancer (PC) patients who showed a single finding on bone scintigraphy (BS) that was classified as equivocal or suspected for metastatic lesion. MATERIALS AND METHODS: A total of 25 PC patients with biochemical failure (mean PSA value 11.1 ng/mL; median value 6.3 ng/mL; range 0.2-37.7 ng/mL) after primary treatment were included in this retrospective study. All of them showed a single lesion on BS reported as suspected for metastatic lesion or as equivocal finding. Patients underwent (11)C-choline PET/CT within 1-4 months from BS. Validation was established by follow-up for at least 6 months. RESULTS: On the basis of biopsy confirmation and/or 6-month follow-up, 22 of 25 patients were classified as positive for the presence of metastatic bone lesions: 13 with a single lesion and 9 with multiple lesions. (11)C-choline PET/CT was positive in 19/25 patients and, on a lesion basis, it showed 50 positive findings. BS results were confirmed in 8/25 (32%) patients. (11)C-choline PET/CT detected multiple sites of relapse in 11/25 (44%) patients: in 2/11, a single bone lesion associated with other extraosseous sites of relapse; in 6/11, multiple bone lesions; in 3/11, multiple bone lesions and other extraosseous localizations. Finally, 6/25 patients were negative on (11)C-choline PET/CT. In 3/6 patients, an osteoblastic lesion was seen on CT attenuation correction images (PET false negative; BS true positive), while in 3/6 patients only findings suggestive of the presence of degenerative disease were found (PET true negative; BS false positive). On a patient basis, (11)C-choline PET/CT showed a diagnostic sensitivity of 86% (19/22) and a specificity of 100% (19/19). CONCLUSIONS: In our study, (11)C-choline PET/CT detected unknown lesions in 11/25 patients. Patients with a single equivocal finding on BS could have important additional information from (11)C-choline PET/CT study, especially in the detection of additional metastases, to choose an appropriate treatment. |
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Authors:
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Chiara Fuccio; Paolo Castellucci; Riccardo Schiavina; Ivan Santi; Vincenzo Allegri; Vincenzina Pettinato; Stefano Boschi; Giuseppe Martorana; Adil Al-Nahhas; Domenico Rubello; Stefano Fanti |
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Publication Detail:
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Type: Journal Article Date: 2010-06-11 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 24 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 485-92 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Unit, Hematology-Oncology and Laboratory Medicine Department, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, University of Bologna, Bologna, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bone Neoplasms / radionuclide imaging*, secondary Carbon Radioisotopes / diagnostic use Choline / diagnostic use* Humans Male Middle Aged Neoplasm Staging Positron-Emission Tomography* Prostatic Neoplasms / diagnosis*, pathology*, radiography, radionuclide imaging Retrospective Studies Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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