Document Detail

Rofecoxib and tramadol do not attenuate delayed-onset muscle soreness or ischaemic pain in human volunteers.
MedLine Citation:
PMID:  16462914     Owner:  NLM     Status:  MEDLINE    
We assessed the effect of rofecoxib, a cyclo-oxygenase-2 inhibitor, and tramadol, a centrally acting analgesic, on both delayed-onset muscle soreness (DOMS) and experimentally induced ischaemic pain. We induced DOMS in 10 male and 5 female healthy volunteers by downhill running for 30 min at a 12% decline and a speed of 9 km x h(-1). We also induced ischaemic pain by finger movements with an arterial tourniquet around the arm. In a randomized, double-blind crossover format, we administered rofecoxib (50 mg, daily), tramadol (50 mg, 3 times per day), and a placebo (orally for 3 days), starting immediately after exercise. A 100 mm visual analogue scale (VAS) and McGill pain questionnaire were used to describe muscle soreness and ischaemic forearm pain 24 h after the exercise. The pressure pain threshold (PPT) in the thigh and ischaemic pain tolerance in the forearm were measured before exercise and 24 and 72 h after exercise. PPT decreased 24 h after exercise, compared with pre-exercise values (ANOVA, p < 0.05), but neither drug had any significant effect on the PPT. Neither rofecoxib nor tramadol had any effect on time of ischaemia tolerated or amount of finger activity during ischaemia. The VAS and pain-rating index, for both muscle soreness and experimental ischaemic pain, were not affected significantly by either drug. Both DOMS and ischaemic pain share peripheral and central mechanisms, yet neither are attenuated by rofecoxib or tramadol.
L C Loram; D Mitchell; A Fuller
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  83     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1137-45     Citation Subset:  IM    
Brain Function Research Unit, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
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MeSH Terms
Creatine Kinase / metabolism
Cross-Over Studies
Cyclooxygenase 2 Inhibitors / pharmacology*
Double-Blind Method
Exercise / physiology
Forearm / blood supply,  physiology
Ischemia / complications
Lactones / pharmacology*
Muscular Diseases / complications*
Narcotics / pharmacology*
Pain / etiology,  prevention & control*
Pain Measurement / drug effects
Regional Blood Flow / physiology
Sulfones / pharmacology*
Tramadol / pharmacology*
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Lactones; 0/Narcotics; 0/Sulfones; 0/rofecoxib; 27203-92-5/Tramadol; EC Kinase

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