Document Detail

Rodent facial nerve recovery after selected lesions and repair techniques.
MedLine Citation:
PMID:  20048604     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Measuring rodent facial movements is a reliable method for studying recovery from facial nerve manipulation and for examining the behavioral correlates of aberrant regeneration. The authors quantitatively compared recovery of vibrissal and ocular function following three types of clinically relevant nerve injury.
METHODS: One hundred seventy-eight adult rats underwent facial nerve manipulation and testing. In the experimental groups, the left facial nerve was either crushed, transected, and repaired epineurially, or transected and the stumps suture-secured into a tube with a 2-mm gap between them. Facial recovery was measured for the ensuing 1 to 4 months. Data were analyzed for whisking recovery. Previously developed markers of co-contraction of the upper and midfacial zones (possible synkinesis markers) were also examined.
RESULTS: Animals in the crush groups recovered nearly normal whisking parameters within 25 days. The distal branch crush group showed improved recovery over the main trunk crush group for several days during early recovery. By week 9, the transection/repair groups showed evidence of recovery that trended further upward throughout the study period. The entubulation groups followed a similar recovery pattern, although they did not maintain significant recovery levels by the study conclusion. Markers of potential synkinesis increased in selected groups following facial nerve injury.
CONCLUSIONS: Rodent vibrissal function recovers in a predictable fashion following manipulation. Generalized co-contraction of the upper and midfacial zones emerges following facial nerve manipulation, possibly related to aberrant regeneration, polyterminal axons, or hypersensitivity of the rodent to sensory stimuli following nerve manipulation.
Tessa A Hadlock; Jeffrey Kowaleski; David Lo; Susan E Mackinnon; James T Heaton
Related Documents :
8958494 - Electromyographic facial nerve monitoring during resection for acoustic neurinoma under...
10765054 - The development of synkinesis after facial nerve paralysis.
16421884 - Sensitivity of repetitive facial-nerve stimulation in patients with myasthenia gravis.
2334104 - Current trends in the treatment of established unilateral facial palsy.
7592224 - Influence of background vagal c-fiber activity on eupneic breathing pattern in anesthet...
1470314 - Force, fatigue, and the cross-sectional area of wrist extensor muscles after radial ner...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  125     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-02-16     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-109     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blinking / physiology
Facial Nerve / surgery*
Facial Nerve Injuries / physiopathology,  surgery*
Models, Animal
Neural Conduction / physiology
Peripheral Nerves / surgery
Rats, Wistar
Recovery of Function* / physiology
Vibrissae / innervation,  physiology*
Grant Support
K-08 DE015665-01A2/DE/NIDCR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of epidural anesthesia on muscle flap tolerance to venous ischemia.
Next Document:  Treatment of earlobe keloids by extralesional excision combined with preoperative and postoperative ...