| Rodent cardiovascular responses to baroreceptor unloading: Effect of plane of anaesthesia. | |
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MedLine Citation:
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PMID: 21574778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The objective of this study was to determine whether a plane of urethane-α-chloralose anaesthesia that suppresses motor reflexes would affect baroreflex cardiovascular control relative to a plane of anaesthesia that leaves motor reflexes intact. Adult male Sprague-Dawley rats were anaesthetized to either a light (motor reflexes intact) or deep (motor reflexes suppressed) plane of anaesthesia. Animals were exposed to graded (-2 to -10 mm Hg) lower body negative pressure while heart rate, vascular resistance, and mean arterial pressure were assessed. No between-group differences were observed in baseline hemodynamics. Graded lower body negative pressure progressively increased heart rate (p < 0.01) and vascular resistance (p < 0.001) and reduced mean arterial pressure (p < 0.001) similarly in light and deep planes of anaesthesia. Therefore, the deep plane of anaesthesia was not associated with a degradation of the autonomic response to baroreceptor unloading beyond that observed at the light plane. These data support the use of urethane-α-chloralose anaesthesia in studies examining reflex cardiovascular control concomitant with some degree of noxious stimulation. |
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Authors:
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Charlotte W Usselman; Louis Mattar; Jasna Twynstra; Ian Welch; J Kevin Shoemaker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-16 |
Journal Detail:
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Title: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Volume: - ISSN: 1715-5312 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Neurovascular Research Laboratory, School of Kinesiology, The University of Western Ontario, London, ON N6A 3K7, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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