| Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. | |
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MedLine Citation:
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PMID: 20711184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In mammals, synchronization of the circadian pacemaker in the hypothalamus is achieved through direct input from the eyes conveyed by intrinsically photosensitive retinal ganglion cells (ipRGCs). Circadian photoentrainment can be maintained by rod and cone photoreceptors, but their functional contributions and their retinal circuits that impinge on ipRGCs are not well understood. Using mice that lack functional rods or in which rods are the only functional photoreceptors, we found that rods were solely responsible for photoentrainment at scotopic light intensities. Rods were also capable of driving circadian photoentrainment at photopic intensities at which they were incapable of supporting a visually guided behavior. Using mice in which cone photoreceptors were ablated, we found that rods signal through cones at high light intensities, but not at low light intensities. Thus, rods use two distinct retinal circuits to drive ipRGC function to support circadian photoentrainment across a wide range of light intensities. |
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Authors:
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Cara M Altimus; Ali D Güler; Nazia M Alam; A Cyrus Arman; Glen T Prusky; Alapakkam P Sampath; Samer Hattar |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-15 |
Journal Detail:
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Title: Nature neuroscience Volume: 13 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-26 Completed Date: 2010-10-04 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1107-12 Citation Subset: IM |
Affiliation:
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Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circadian Rhythm / physiology* Cyclic Nucleotide-Gated Cation Channels / deficiency, genetics, metabolism GTP-Binding Protein alpha Subunits / deficiency, genetics, metabolism Male Membrane Potentials Mice Mice, Knockout Mice, Transgenic Motor Activity / physiology Neural Pathways / physiology Neurons / physiology Patch-Clamp Techniques Photic Stimulation Retina / physiology Retinal Bipolar Cells / physiology Retinal Cone Photoreceptor Cells / physiology Retinal Rod Photoreceptor Cells / physiology* Rod Opsins / deficiency, genetics, metabolism Transducin / deficiency, genetics, metabolism Visual Perception / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY017606/EY/NEI NIH HHS; GM076430/GM/NIGMS NIH HHS; R01 GM076430-04/GM/NIGMS NIH HHS; R01 GM076430-05/GM/NIGMS NIH HHS; R01 GM076430-06/GM/NIGMS NIH HHS; R01 GM076430-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cnga3 protein, mouse; 0/Cyclic Nucleotide-Gated Cation Channels; 0/GTP-Binding Protein alpha Subunits; 0/Gnat1 protein, mouse; 0/Rod Opsins; 0/melanopsin; EC 3.6.1.-/Transducin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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