| Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling. | |
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MedLine Citation:
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PMID: 20375363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The identification of one mechanism that causes vision loss in inherited degenerative retinal disorders revealed a new signaling molecule that represents a potential therapy for these currently untreatable diseases. This protein, called rod-derived cone viability factor (RdCVF), maintains the function and consequently the viability of cone photoreceptor cells in the retina; mice that lack this factor exhibit a progressive loss of photoreceptor cells. The gene encoding RdCVF also encodes, by differential splicing, a second product that has characteristics of a thioredoxin-like enzyme and protects both photoreceptor cells and, more specifically, its interacting protein partner, the tau protein, against oxidative damage. This signaling pathway potentially links environmental insults to an endogenous neuroprotective response. |
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Authors:
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Thierry Léveillard; José-Alain Sahel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science translational medicine Volume: 2 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-09-20 Revised Date: 2010-10-04 |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 26ps16 Citation Subset: IM |
Affiliation:
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Department of Genetics, Institut de la Vision, INSERM, UPMC University of Paris 06, UMR-S 968, CNRS 7210, Paris F-75012, France. thierry.leveillard@inserm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blindness / therapy* Cell Survival Humans Mice Oxidation-Reduction Oxidative Stress Retinal Cone Photoreceptor Cells / metabolism* Retinal Degeneration / therapy Retinal Diseases / therapy Retinal Rod Photoreceptor Cells / metabolism* Signal Transduction* Thioredoxins / genetics, metabolism* Translational Research* |
| Chemical | |
Reg. No./Substance:
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52500-60-4/Thioredoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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