| Rod, M-cone and M/S-cone inputs to hyperpolarizing bipolar cells in the mouse retina. | |
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MedLine Citation:
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PMID: 22219344 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Bipolar cells are the central neurons of the retina that convey visual signals from rod and cone photoreceptors in the outer retina to higher-order neurons in the inner retina and the brain. Early anatomical studies have suggested that there are 4 types of cone hyperpolarizing (OFF) bipolar cells (HBCs) in the mouse retina, but no light responses have been systematically examined. By analyzing light-evoked cation and chloride currents (ΔIC and ΔICl) from over 50 morphologically-identified HBCs in the dark-adapted wildtype and connexin36 knockout (Cx36-/-) mouse retinas, we identified three types of HBCs, each with distinct light responses and morphological characteristics. The HBCR/MCs with axon terminals ramifying between 0% and 30% of the inner plexiform layer (IPL) receive mixed inputs from rods and M-cones, the HBCMCs with axon terminals ramifying between 10% and 50% of the IPL receive inputs primarily from M-cones, and the HBCM/SCs with axon terminals ramifying between 25% and 50% of IPL receive inputs primarily from cones with mixed M- and S-cone pigments. Moreover, we found that HBCR/MCs in the Cx36-/- mice exhibit light responses very similar to the wildtype HBCR/MCs, suggesting that the mixed rod/cone inputs are not mediated by connexin36-dependent rod-cone coupling, but rather by direct synaptic contacts from rods and M-cones. This study constitutes the first systematic investigation that correlates light response characteristics and axonal morphology of HBCs in dark-adapted mouse retina, and contributes to recently emerging evidence that revises the traditional view that mammalian HBCs only contact cone photoreceptors. |
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Authors:
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Ji-Jie Pang; Fan Gao; David L Paul; Samuel M Wu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-4 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Baylor College of Medicine; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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