| Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits. | |
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MedLine Citation:
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PMID: 20006149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The goal of this study was to investigate the effect of rocuronium and vecuronium continuous infusion on oral tissue blood flow in rabbits. MATERIALS AND METHODS: We used 8 male Japan White rabbits. The infusion rates of rocuronium were 7, 14, and 28 microg kg(-1) min(-1) for 20 minutes, in this order. After rocuronium was discontinued and body movement confirmed, continuous infusion of vecuronium was started. The infusion rates of vecuronium were 1.6, 3.2, and 6.4 microg kg(-1) min(-1) for 20 minutes, in this order. Observed variables were systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, common carotid artery blood flow, tongue mucosal blood flow, oxygen partial pressure of the mandibular bone marrow, and oxygen partial pressure of the masseter muscle. RESULTS: Heart rate in both groups tended to decrease depending on the infusion rate. Common carotid artery blood flow in the rocuronium group was increased depending on the infusion rate. Tongue mucosal blood flow in the vecuronium group was decreased depending on the infusion rate. There were no differences in diastolic blood pressure, mean arterial pressure, oxygen partial pressure of the mandibular bone marrow, and oxygen partial pressure of the masseter muscle between the 2 groups. Systolic blood pressure in both groups showed no major change. CONCLUSION: Rocuronium and vecuronium did not change mandibular bone marrow and masseter muscular blood flows. Vecuronium decreased tongue mucosal blood flow depending on the infusion rate. |
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Authors:
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Yui Terakawa; Tatsuya Ichinohe; Yuzuru Kaneko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Volume: 68 ISSN: 1531-5053 ISO Abbreviation: J. Oral Maxillofac. Surg. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206428 Medline TA: J Oral Maxillofac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: AIM; D; IM |
Affiliation:
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Department of Dental Anesthesiology, Tokyo Dental College, Mihama-ku, Chiba, Japan. terakawayui@tdc.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstanols
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pharmacology* Anesthesia, General Animals Blood Pressure / drug effects Bone Marrow / blood supply* Heart Rate / drug effects Infusions, Intravenous Male Mandible / blood supply* Masseter Muscle / blood supply* Neuromuscular Nondepolarizing Agents / pharmacology* Oxygen / metabolism Partial Pressure Rabbits Tongue / blood supply Vecuronium Bromide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium; 50700-72-6/Vecuronium Bromide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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